Quaternary Structure: Subunits

Interleukin 10 receptor, β subunit (Ligand-binding subunit)

Interleukin 22 receptor, α1 subunit (Ligand-binding subunit)

Natural/Endogenous Ligands
IL-22 {Sp: Human}

Download all structure-activity data for this target as a CSV file

Agonists
Key to terms and symbols		Click column headers to sort
Ligand Sp. Action Value Parameter Reference IL-22 {Sp: Human} Hs Agonist 11.5 pEC50 1 ⤷ pEC50 11.5 (EC50 3.5x10-12 M) [1] Description: EC50 for rhIL-22-induced STAT3 activation in HEK293 cells that overexpress the human IL-22 heterodimeric receptor efmarodocokin alfa Hs Agonist 9.9 pEC50 1 ⤷ pEC50 9.9 (EC50 1.2x10-10 M) [1] Description: EC50 for fusion protein-induced STAT3 activation in HEK293 cells that overexpress the human IL-22 heterodimeric receptor

Immunopharmacology Comments

This is a heterodimeric receptor containing interleukin 10 receptor, β subunit (IL10RB) and interleukin 22 receptor, α1 subunit (IL22RA1). It is a receptor for interleukin 22.