IL-21   Click here for help

GtoPdb Ligand ID: 4987

Synonyms: interleukin-21 | ZA11
Immunopharmacology Ligand
Comment: IL-21 acts via the IL-21 receptor expressed on the surface of T, B and NK cells.
Species: Human
Bioactivity Comments
IL-21 has been shown to eliminate glioblastoma multiforme cells via activation of the cytolytic reactivity of Vγ9Vδ2 T cells in vitro and in an in vivo model [1]. These findings suggest that IL-21-sensitized allogeneic human Vγ9Vδ2 T cells might offer a novel immunotherapeutic approach for the treatment of glioblastoma multiforme.
Natural/Endogenous Targets
Interleukin-21 receptor
Selectivity at catalytic receptors
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
Interleukin-21 receptor Ligand is endogenous in the given species Hs Agonist Agonist - - -