- Guide to PHARMACOLOGY
Synonyms: interleukin-21 | ZA11
Compound class: Endogenous peptide in human, mouse or rat
Comment: IL-21 acts via the IL-21 receptor expressed on the surface of T, B and NK cells.
|IL-21 has been shown to eliminate glioblastoma multiforme cells via activation of the cytolytic reactivity of Vγ9Vδ2 T cells in vitro and in an in vivo model . These findings suggest that IL-21-sensitized allogeneic human Vγ9Vδ2 T cells might offer a novel immunotherapeutic approach for the treatment of glioblastoma multiforme.|
|Selectivity at catalytic receptors|
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