- Guide to PHARMACOLOGY
Synonyms: embonic acid
Compound class: Synthetic organic
Comment: Many salts and esters or pamoates are commecially available and are often used in bio-assays in place of pamoic acid.
Although not an approved drug itself, pamoic acid is a component of the INN-assigned compounds listed above.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
|Selectivity at GPCRs|
|Key to terms and symbols||Click column headers to sort|
|Targets where the ligand is described in the comment field|
|GPR35||Several studies have shown that kynurenic acid is an agonist of GPR35 but it remains controversial whether the proposed endogenous ligand reaches sufficient tissue concentrations to activate the receptor . 2-Oleoyl-LPA has also been proposed as an endogenous ligand  but these results were not replicated in an arrestin assay . The phosphodiesterase inhibitor zaprinast  has become widely used as a surrogate agonist to investigate GPR35 pharmacology and signalling . GPR35 is also activated by the pharmaceutical adjunct pamoic acid . See reviews  and .|