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ChEMBL ligand: CHEMBL177880 (Pamoic Acid) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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DNA polymerase beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2392] [UniProtKB: P06746] | ||||||||
ChEMBL | Inhibition of DNA polymerase beta (unknown origin) | B | 5.05 | pIC50 | 9000 | nM | IC50 | J. Med. Chem. (2013) 56: 5182-5197 [PMID:23713606] |
GPR35/G-protein coupled receptor 35 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1293267] [GtoPdb: 102] [UniProtKB: Q9HC97] | ||||||||
ChEMBL | Displacement of [3H]PSB-13253 from human recombinant GPR35 exprssed in CHO cells by liquid scintillation counting analysis | B | 7.94 | pKi | 11.5 | nM | Ki | J. Med. Chem. (2013) 56: 7084-7099 [PMID:23888932] |
ChEMBL | Agonist activity at C-terminal beta-galactosidase tagged human recombinant GPR35 expressed in CHO cells after 90 mins by beta-arrestin recruitment assay | B | 5.92 | pEC50 | 1200 | nM | EC50 | J. Med. Chem. (2013) 56: 7084-7099 [PMID:23888932] |
ChEMBL | Agonist activity at human GPR35 expressed in CHO-K1 cells after 90 mins by beta-arrestin 2 recruitment assay | B | 6.3 | pEC50 | 500 | nM | EC50 | J Med Chem (2017) 60: 362-372 [PMID:27976894] |
ChEMBL | Agonist activity at human GPR35 receptor expressed in HEK293T cells co-expressing beta-arrestin2 assessed as induction of beta-arrestin2 recruitment by BRET assay | F | 6.3 | pEC50 | 500 | nM | EC50 | J Med Chem (2021) 64: 2634-2647 [PMID:33630609] |
GtoPdb | - | - | 7.29 | pEC50 | - | - | - | Biochem J (2010) 432: 451-9 [PMID:20919992] |
ChEMBL | Agonist activity at human GPR35 expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase reporter gene assay | B | 7.3 | pEC50 | 50 | nM | EC50 | J. Med. Chem. (2013) 56: 5182-5197 [PMID:23713606] |
ChEMBL | Agonist activity at human GPR35 by DMR assay | B | 8.68 | pEC50 | 2.1 | nM | EC50 | J. Med. Chem. (2013) 56: 7084-7099 [PMID:23888932] |
ChEMBL | Agonist activity at human GPR35 expressed in CHO-K1 cells by DMR assay | B | 8.7 | pEC50 | 2 | nM | EC50 | J Med Chem (2017) 60: 362-372 [PMID:27976894] |
ChEMBL | Agonist activity at human GPR35 receptor expressed in HT-29 cells assessed as dynamic mass redistribution response measured for 60 mins by DMR assay | F | 8.7 | pEC50 | 2 | nM | EC50 | J Med Chem (2021) 64: 2634-2647 [PMID:33630609] |
GPR35 in Rat [GtoPdb: 102] [UniProtKB: Q33BM1] | ||||||||
GtoPdb | - | - | 5 | pEC50 | - | - | - | Biochem J (2010) 432: 451-9 [PMID:20919992] |
ChEMBL data shown on this page come from version 31:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]