pamoic acid [Ligand Id: 2920] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL177880 (Pamoic Acid)
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
DNA polymerase beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2392] [UniProtKB: P06746]
ChEMBL Inhibition of DNA polymerase beta (unknown origin) B 5.05 pIC50 9000 nM IC50 J. Med. Chem. (2013) 56: 5182-5197 [PMID:23713606]
GPR35/G-protein coupled receptor 35 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1293267] [GtoPdb: 102] [UniProtKB: Q9HC97]
ChEMBL Displacement of [3H]PSB-13253 from human recombinant GPR35 exprssed in CHO cells by liquid scintillation counting analysis B 7.94 pKi 11.5 nM Ki J. Med. Chem. (2013) 56: 7084-7099 [PMID:23888932]
ChEMBL Agonist activity at C-terminal beta-galactosidase tagged human recombinant GPR35 expressed in CHO cells after 90 mins by beta-arrestin recruitment assay B 5.92 pEC50 1200 nM EC50 J. Med. Chem. (2013) 56: 7084-7099 [PMID:23888932]
ChEMBL Agonist activity at human GPR35 expressed in CHO-K1 cells after 90 mins by beta-arrestin 2 recruitment assay B 6.3 pEC50 500 nM EC50 J Med Chem (2017) 60: 362-372 [PMID:27976894]
ChEMBL Agonist activity at human GPR35 receptor expressed in HEK293T cells co-expressing beta-arrestin2 assessed as induction of beta-arrestin2 recruitment by BRET assay F 6.3 pEC50 500 nM EC50 J Med Chem (2021) 64: 2634-2647 [PMID:33630609]
GtoPdb - - 7.29 pEC50 - - - Biochem J (2010) 432: 451-9 [PMID:20919992]
ChEMBL Agonist activity at human GPR35 expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase reporter gene assay B 7.3 pEC50 50 nM EC50 J. Med. Chem. (2013) 56: 5182-5197 [PMID:23713606]
ChEMBL Agonist activity at human GPR35 by DMR assay B 8.68 pEC50 2.1 nM EC50 J. Med. Chem. (2013) 56: 7084-7099 [PMID:23888932]
ChEMBL Agonist activity at human GPR35 expressed in CHO-K1 cells by DMR assay B 8.7 pEC50 2 nM EC50 J Med Chem (2017) 60: 362-372 [PMID:27976894]
ChEMBL Agonist activity at human GPR35 receptor expressed in HT-29 cells assessed as dynamic mass redistribution response measured for 60 mins by DMR assay F 8.7 pEC50 2 nM EC50 J Med Chem (2021) 64: 2634-2647 [PMID:33630609]
GPR35 in Rat [GtoPdb: 102] [UniProtKB: Q33BM1]
GtoPdb - - 5 pEC50 - - - Biochem J (2010) 432: 451-9 [PMID:20919992]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]