27-hydroxycholesterol   Click here for help

GtoPdb Ligand ID: 2752

Synonyms: 26-hydroxycholesterol | 27-OHC
Compound class: Metabolite
Comment: CID 99470 shows another representation of the stereochemistry of 27-hydroxycholesterol which is commonly reported in the literature.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species

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2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 2
Hydrogen bond donors 2
Rotatable bonds 6
Topological polar surface area 40.46
Molecular weight 402.35
XLogP 8.54
No. Lipinski's rules broken 1
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES OCC(CCCC(C1CCC2C1(C)CCC1C2CC=C2C1(C)CCC(C2)O)C)C
Isomeric SMILES OC[C@@H](CCC[C@H]([C@H]1CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2CC=C2[C@]1(C)CC[C@@H](C2)O)C)C
InChI InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18-,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
InChI Key FYHRJWMENCALJY-YSQMORBQSA-N
Natural/Endogenous Targets
Target
GPR183
Liver X receptor-α
Liver X receptor-β
Selectivity at GPCRs
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
GPR183 Ligand is endogenous in the given species Hs Agonist Agonist 5.5 pEC50 - 4
⤷ pEC50 5.5 (EC50 3.029x10-6 M) [4]
Selectivity at nuclear hormone receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
Liver X receptor-β Ligand is endogenous in the given species Hs Agonist Agonist 7.2 pEC50 - 2
⤷ pEC50 7.2 [2]
Liver X receptor-α Ligand is endogenous in the given species Hs Agonist Agonist 7.1 pEC50 - 2
⤷ pEC50 7.1 [2]
Additional information and targets (data relate to human unless otherwise stated)
Description Data Reference
Potency order at Liver X receptor-α 20S-hydroxycholesterol, 22R-hydroxycholesterol, 24(S)-hydroxycholesterol > 25-hydroxycholesterol, 27-hydroxycholesterol 3
Potency order at Liver X receptor-β 20S-hydroxycholesterol, 22R-hydroxycholesterol, 24(S)-hydroxycholesterol > 25-hydroxycholesterol, 27-hydroxycholesterol 3
Targets where the ligand is described in the comment field
Target Comment
CYP27A1 Converts cholesterol to 27-hydroxycholesterol. Autosomal-recessive mutations in CYP27A1 cause the bile acid metabolism disorder cerebrotendinous xanthomatosis (CTX, cerebral cholesterosis) [1,5]. An adenovirus vector encoding human CYP27A1 (VTX-806; Vivet Therapeutics) is being trialled as a gene replacement therapy for CTX. VTX-806 was granted Orphan Drug Designation by the EMA in September 2024 for this rare disease.