salvianolic acid A   Click here for help

GtoPdb Ligand ID: 13093

Synonyms: Dan Phenolic Acid A | Danshen | Sal A
Immunopharmacology Ligand
Compound class: Natural product or derivative
Comment: Salvianolic acid A is a plant-derived stilbenoid. A number of salvianolic acids have been extracted from a range of plants, some of which are used in Chinese herbal medicines (e.g. Danshen, Salvia miltiorrhiza). The therapeutic potential of salvianolic acids is under investigation [4], based on their proposed pharmacological effects which include anti-oxidant, anti-fibrotic, anti-coagulant/anti-thrombotic and anti-tumour activities [6-7].
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 10
Hydrogen bond donors 7
Rotatable bonds 9
Topological polar surface area 184.98
Molecular weight 494.45
XLogP 2.63
No. Lipinski's rules broken 1
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES C(=C\C1=C(C(=CC=C1/C=C/C(=O)O[C@H](CC2=CC=C(C(=C2)O)O)C(=O)O)O)O)/C3=CC=C(C(=C3)O)O
Isomeric SMILES C1=CC(=C(C=C1C[C@H](C(=O)O)OC(=O)/C=C/C/2=C(\C(=C(C=C2)O)O)/C=C/C3=CC(=C(C=C3)O)O)O)O
InChI InChI=1S/C26H22O10/c27-18-7-2-14(11-21(18)30)1-6-17-16(4-9-20(29)25(17)33)5-10-24(32)36-23(26(34)35)13-15-3-8-19(28)22(31)12-15/h1-12,23,27-31,33H,13H2,(H,34,35)/b6-1+,10-5+/t23-/m1/s1
InChI Key YMGFTDKNIWPMGF-UCPJVGPRSA-N
Bioactivity Comments
Potent inhibition of human carbonic anhydrases has been reported [2]. Mechanistically salvianolic acid A has been shown to bind directly to the pyruvate kinase isozyme PKM2 and to inhibit its phosphorylation and nuclear translocation [7]. This mechanism reduces pyroptotic cell death in endothelial cells and ameliorates formation of atherosclerotic lesions in a diabetic mouse model.
Selectivity at enzymes
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
carbonic anhydrase 12 Hs Inhibitor Inhibition 7.4 pKi - 2
⤷ pKi 7.4 (Ki 3.98x10-8 M) [2]
carbonic anhydrase 4 Hs Inhibitor Inhibition 7.2 pKi - 2
⤷ pKi 7.2 (Ki 6.69x10-8 M) [2]
carbonic anhydrase 7 Hs Inhibitor Inhibition 7.2 pKi - 2
⤷ pKi 7.2 (Ki 7.14x10-8 M) [2]
carbonic anhydrase 2 Hs Inhibitor Inhibition 5.0 pKi - 2
⤷ pKi 5.0 (Ki 9.594x10-6 M) [2]