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Target id: 3092
Nomenclature: carbonic anhydrase 2
Abbreviated Name: CA II
Family: Carbonic anhydrases
Gene and Protein Information | ||||||
Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | 260 | 8q21.2 | CA2 | carbonic anhydrase 2 | |
Mouse | - | 260 | 3 3.23 cM | Car2 | carbonic anhydrase 2 | |
Rat | - | 260 | 2q23 | Car2 | carbonic anhydrase 2 | |
Gene and Protein Information Comments | ||||||
Two transcript variants encoding different isoforms have been identified for the human and mouse genes. |
Previous and Unofficial Names |
CAII | Car2 | carbonic anhydrase II |
Database Links | |
Alphafold | P00918 (Hs), P00920 (Mm), P27139 (Rn) |
BRENDA | 4.2.1.1 |
ChEMBL Target | CHEMBL205 (Hs), CHEMBL3689 (Mm), CHEMBL4706 (Rn) |
Ensembl Gene | ENSG00000104267 (Hs), ENSMUSG00000027562 (Mm), ENSRNOG00000009629 (Rn) |
Entrez Gene | 760 (Hs), 12349 (Mm), 54231 (Rn) |
Human Protein Atlas | ENSG00000104267 (Hs) |
KEGG Enzyme | 4.2.1.1 |
KEGG Gene | hsa:760 (Hs), mmu:12349 (Mm), rno:54231 (Rn) |
OMIM | 611492 (Hs) |
Pharos | P00918 (Hs) |
RefSeq Nucleotide | NM_000067 (Hs), NM_009801 (Mm), NM_019291 (Rn) |
RefSeq Protein | NP_000058 (Hs), NP_033931 (Mm), NP_062164 (Rn) |
UniProtKB | P00918 (Hs), P00920 (Mm), P27139 (Rn) |
Wikipedia | CA2 (Hs) |
Enzyme Reaction | ||||
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Download all structure-activity data for this target as a CSV file
Inhibitors | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Immuno Process Associations | ||
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1. Berrino E, Milazzo L, Micheli L, Vullo D, Angeli A, Bozdag M, Nocentini A, Menicatti M, Bartolucci G, di Cesare Mannelli L et al.. (2019) Synthesis and Evaluation of Carbonic Anhydrase Inhibitors with Carbon Monoxide Releasing Properties for the Management of Rheumatoid Arthritis. J Med Chem, 62 (15): 7233-7249. [PMID:31287314]
2. Karioti A, Ceruso M, Carta F, Bilia AR, Supuran CT. (2015) New natural product carbonic anhydrase inhibitors incorporating phenol moieties. Bioorg Med Chem, 23 (22): 7219-25. [PMID:26498393]
3. Oztürk Sarikaya SB, Topal F, Sentürk M, Gülçin I, Supuran CT. (2011) In vitro inhibition of α-carbonic anhydrase isozymes by some phenolic compounds. Bioorg Med Chem Lett, 21 (14): 4259-62. [PMID:21669522]
Carbonic anhydrases: carbonic anhydrase 2. Last modified on 05/11/2024. Accessed on 13/12/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=3092.