- Guide to PHARMACOLOGY
Synonyms: MMV1582617 | NVP-INE963
Compound class: Synthetic organic
Comment: INE963 is a potent antimalarial compound identified by the Novartis Institute for Tropical Diseases (NITD) during an optimization study of a series of 5-aryl-2-amino-imidazothiadiazole (ITD) derivatives . The compound has progressed to clinical evaluation and was awarded MMV Project of the Year (2019).
The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY.
|In addition to single digit nanomolar activity against the asexual blood stage of P. falciparum 3D7 (see table below), INE963 demonstrates potent activity against drug-resistant P. falciparum cell lines (EC50 of 0.5-15 nM) . The same study reports potency against P. falciparum and P. vivax clinical isolates from Brazil and Uganda (EC50 of 0.01-7.0 nM).|
|Whole organism assay data|
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