Synonyms: GS-441524 triphosphate | GS-443902 | RDV-TP
Compound class:
Synthetic organic
Comment: Remdesivir triphosphate (GS-443902) is a metabolite of remdesivir. It is formed by replacement of the 5'-hydroxyl group of GS-441524 by a triphosphate group. It inhibits RNA-dependent RNA polymerase (RdRP) activity in a range of viruses.
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Bioactivity Comments |
Originally developed for antiviral activity against Ebola virus (EBOV), but has activity against other viruses due to the structural similarities of their RNA-dependent RNA polymerases [1]. |