Synonyms: compound 4b [PMID: 28124907] | GS-5734 | GS5734 | Veklury®
remdesivir is an approved drug (FDA & EMA (2020))
Compound class:
Synthetic organic
Comment: Remdesivir (GS-5734) is a nucleotide analogue drug that was developed by Gilead Sciences for antiviral potential, in particular for anti-Ebola and anti-Marburg virus activity [7]. It acts is an inhibitor of the viral RNA-dependent RNA polymerase (RdRP) that functions as a chain terminator during viral RNA synthesis. Remdesivir is a prodrug whose major active metabolite is GS-441524. Its 1'-CN group and C-linked nucleobase ensure optimal anti-Ebola potency and selectivity against host polymerase enzymes. Remdesivir has broad-spectrum activity against several viral families such as filoviruses, paramyxoviruses, and coronaviruses, and including the SARS and MERS coronaviruses (CoVs), endemic circulating human CoVs, and against SARS-CoV-2 [1-2,6]. The first patient to test positive for SARS-CoV-2 in the US was treated with i.v. remdesivir (using compassionate use of an investigational therapy prescribing) and his clinical condition improved significantly within the next 24h without observation of adverse effects [4].
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Classification ![]() |
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Compound class | Synthetic organic |
Approved drug? | Yes (FDA & EMA (2020)) |
Approved drug? | Yes. EMA (2020) | FDA (2020) |
Is prodrug? | Yes |
Active form | GS-441524 |
IUPAC Name ![]() |
2-ethylbutyl (2S)-2-[[[(2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxyoxolan-2-yl]methoxy-phenoxyphosphoryl]amino]propanoate |
International Nonproprietary Names ![]() |
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INN number | INN |
10478 | remdesivir |
Synonyms ![]() |
compound 4b [PMID: 28124907] | GS-5734 | GS5734 | Veklury® |
Database Links ![]() |
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Specialist databases | |
Reactome Drug
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R-ALL-9680278 |
Reactome Reaction
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R-HSA-9687384, R-HSA-9687388, R-HSA-9680262, R-HSA-9694665, R-HSA-9694541, R-HSA-9694419 |
Other databases | |
CAS Registry No. | 1809249-37-3 (source: WHO INN record) |
ChEMBL Ligand | CHEMBL4065616 |
DrugCentral Ligand | 5376 |
GtoPdb PubChem SID | 404859162 |
PubChem CID | 121304016 |
Search Google for chemical match using the InChIKey | RWWYLEGWBNMMLJ-YSOARWBDSA-N |
Search Google for chemicals with the same backbone | RWWYLEGWBNMMLJ |
Search PubMed clinical trials | remdesivir |
Search PubMed titles | remdesivir |
Search PubMed titles/abstracts | remdesivir |
UniChem Compound Search for chemical match using the InChIKey | RWWYLEGWBNMMLJ-YSOARWBDSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | RWWYLEGWBNMMLJ-YSOARWBDSA-N |
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Remdesivir (links to external site)
Cat. No. HY-104077 |