meplazumab   Click here for help

GtoPdb Ligand ID: 11026

Synonyms: HP6H8 | Ketantin®
Antimalarial Ligand
Compound class: Antibody
Comment: Meplazumab is a humanized IgG2 monoclonal antibody that targets CD147 (basigin). It is being developed by Jiangsu Pacific Meinuoke Bio Pharmaceutical.

The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY.

SARS-CoV-2 and COVID-19: SARS-CoV-2 may utilise CD147 as an additional entry receptor to infect host cells [2]. Meplazumab can block this interaction between CD147 and SARS-CoV-2 spike protein.
Bioactivity Comments
Meplazumab has been evaluated using an in vitro growth inhibition assay against a panel of culture-adapted P. falciparum strains and found to have potent asexual blood stage activity. The EC50 values ranged from 1.81 to ~31.64 ng/mL (panel included Pf3D7, PfDd2, and PfNf54) [4].
Selectivity at other protein targets
Key to terms and symbols Click on species/strain names for details Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
basigin (Ok blood group) Hs Antibody Binding - - -