meplazumab   Click here for help

GtoPdb Ligand ID: 11026

Synonyms: HP6H8 | Ketantin®
Antimalarial Ligand
Compound class: Antibody
Comment: Meplazumab is a humanized IgG2 monoclonal antibody that targets CD147 (basigin). It is being developed by Jiangsu Pacific Meinuoke Bio Pharmaceutical.

The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY.

SARS-CoV-2 and COVID-19: SARS-CoV-2 may utilise CD147 as an additional entry receptor to infect host cells [2]. Meplazumab can block this interaction between CD147 and SARS-CoV-2 spike protein.
Classification Click here for help
Compound class Antibody
Ligand families/groups Antimalarial ligands
Synonyms Click here for help
HP6H8 | Ketantin®
Database Links Click here for help
Specialist databases
IMGT/mAb-DB 932
Other databases
GtoPdb PubChem SID 405560467