Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	1	268	19p13.3	BSG	basigin (Ok blood group)
Gene and Protein Information Comments
Multiple transcript variants encoding different isoforms have been reported for this gene. The most prevalent is Oka (OK1, the 269 aa form). OK2 and OK3 are alternate isoforms.

Previous and Unofficial Names

basigin (Ok blood group | CD147 | Extracellular matrix metalloproteinase inducer (EMMPRIN)

Database Links
ChEMBL Target	CHEMBL3580492
Ensembl Gene	ENSG00000172270 (Hs)
Entrez Gene	682 (Hs)
Human Protein Atlas	ENSG00000172270 (Hs)
KEGG Gene	hsa:682 (Hs)
OMIM	109480 (Hs)
RefSeq Nucleotide	NM_001322243 (Hs), NM_001728 (Hs)
RefSeq Protein	NP_001309172 (Hs), NP_001719 (Hs)
UniProtKB	P35613
Wikipedia	BSG (Hs)

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Antibodies
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Antibody Sp. Action Value Parameter Reference meplazumab Hs Binding - - ⤷

Immunopharmacology Comments

CD147 might induce the production of pro-inflammatory cytokines such as IL-6 in monocytes [1]. Meplazumab (Jiangsu Pacific Meinuoke Bio Pharmaceutical) is a clinical stage anti-CD147 monoclonal that is being repurposed for COVID-19 pneumonia (caused by the coronavirus SARS-CoV-2). In this setting it has potential to both inhibit viral entry into host cells via CD147, and to block CD147-mediated inflammatory signalling.

General Comments

Basigin (CD147) is a multi-functional immunoglobulin superfamily protein that is widely expressed (e.g. in epithelial cells, endothelial cells and leukocytes). It has metalloproteinase-inducing ability, and regulates biological processes including spermatogenesis, expression of the monocarboxylate transporter and the responsiveness of lymphocytes. Endogenous ligands include cyclophilins [2] and some integrins. Basigin is exploited by the merozoite stage of Plasmodium falciparum to invade erythrocytes. CD147 neutralising antibodies can block merozoite invasion of host erythrocytes [3], indcating the potential of basigin as a novel malarial drug target in the host. Meplazumab (Jiangsu Pacific Meinuoke Bio Pharmaceutical) is a clinical stage anti-CD147 monoclonal that is being investigated for potential as both prophylaxis and treatment of malaria.