Synonyms: ACT-128800 | ACT128800 | Compound 8bo [PMID:20446681] | Ponvory®
ponesimod is an approved drug (EMA & FDA (2021))
Compound class:
Synthetic organic
Comment: Ponesimod (ACT-128800) is an orally active sphingosine-1-phosphate (S1P) receptor modulator [1] that was developed as a disease-modifying therapy (DMT) for multiple sclerosis (MS). The compound is reported as a partial S1P4 and S1P5 receptor agonist, with maximum activity 18% and 42% of that induced by the endogenous ligand S1P (at 10μM ACT-128800) [1].
The INN record for ponesimod stipulates the (2R) stereoisomer ((2Z,5Z)-5-{3-chloro-4-[(2R)-2,3-dihydroxypropoxy]phenylmethylidene}-3-(2-methylphenyl)-2-(propylimino)-1,3-thiazolidin-4-one). Selective SIP1 receptor agonists are being developed and investigated for immunomodulatory/immunosuppressant potential in autoimmune diseases. Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Classification | |
Compound class | Synthetic organic |
Approved drug? | Yes (EMA & FDA (2021)) |
IUPAC Name |
(5Z)-5-[[3-chloro-4-[(2R)-2,3-dihydroxypropoxy]phenyl]methylidene]-3-(2-methylphenyl)-2-propylimino-1,3-thiazolidin-4-one |
International Nonproprietary Names | |
INN number | INN |
9150 | ponesimod |
Synonyms |
ACT-128800 | ACT128800 | Compound 8bo [PMID:20446681] | Ponvory® |
Database Links | |
Specialist databases | |
GPCRdb Ligand | ponesimod |
Other databases | |
CAS Registry No. | 854107-55-4 (source: WHO INN record) |
ChEMBL Ligand | CHEMBL1096146 |
DrugCentral Ligand | 5446 |
GtoPdb PubChem SID | 318164839 |
PubChem CID | 11363176 |
Search Google for chemical match using the InChIKey | LPAUOXUZGSBGDU-ULCCENQXSA-N |
Search Google for chemicals with the same backbone | LPAUOXUZGSBGDU |
Search PubMed clinical trials | ponesimod |
Search PubMed titles | ponesimod |
Search PubMed titles/abstracts | ponesimod |
UniChem Compound Search for chemical match using the InChIKey | LPAUOXUZGSBGDU-ULCCENQXSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | LPAUOXUZGSBGDU-ULCCENQXSA-N |