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IL-5   Click here for help

GtoPdb Ligand ID: 4997

Immunopharmacology Ligand
Compound class: Endogenous peptide in human, mouse or rat
Comment: IL-5 is one of the hematopoietic family cytokines. Unlike other family members IL-3 and GM-CSF, IL-5 is a homodimer, consisting of two identical amino acid chains linked by two disulphide bonds
Species: Human
Natural/Endogenous Targets
Target
Interleukin-5 receptor
Interleukin 5 receptor, α subunit
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
Interleukin 5 receptor, α subunit Ligand is endogenous in the given species Hs Agonist Agonist - - -
⤷
Interleukin-5 receptor Ligand is endogenous in the given species Hs Agonist Agonist - - -
⤷
Other ligands which bind to or alter the activity of this ligand
Key to terms and symbols Click column headers to sort
Ligand Sp. Type Action Value Parameter Concentration range (M) Reference
mepolizumab Peptide Approved drug Primary target of this compound Hs Antibody Binding 11.4 pKd - 2
⤷ pKd 11.4 (Kd 4.2x10-12 M) [2]
Description: Binding affinity for recombinant human IL-5.
varokibart Peptide Hs Antibody Binding ~10.7 pKd - 3
⤷ pKd ~10.7 (Kd ~2x10-11 M) [3]
Description: Binding affinity for hIL-5 determined by SPR
reslizumab Peptide Approved drug Primary target of this compound Hs Antibody Binding 8.1 pKd - 1
⤷ pKd 8.1 (Kd 8.9x10-9 M) [1]