chiglitazar   Click here for help

GtoPdb Ligand ID: 12287

Synonyms: Bilessglu® | CS-038 | CS038
Approved drug
chiglitazar is an approved drug (China (2022))
Compound class: Synthetic organic
Comment: Chiglitazar (CS-038) is a synthetic small-molecule pan-agonist of peroxisome proliferator-activated receptors (PPARs) α, δ and γ [2-3]. Structurally this is the S-enantiomer of carfloglitazar (the INN represents the racemic mixture; PubChem CID 9938010). Chiglitazar upregulates the expression of genes downstream of PPARα/δthat are involved in lipid metabolism and thermogenesis. It was developed for potential to treat type 2 diabetes (T2D) and non-alcoholic steatohepatitis (NASH).
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 11
Topological polar surface area 80.56
Molecular weight 572.21
XLogP 8.71
No. Lipinski's rules broken 2
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Canonical SMILES OC(=O)[C@@H](Nc1ccccc1C(=O)c1ccc(cc1)F)Cc1ccc(cc1)OCCn1c2ccccc2c2c1cccc2
Isomeric SMILES c1ccc2c(c1)c1ccccc1n2CCOc1ccc(cc1)C[C@@H](C(=O)O)Nc1ccccc1C(=O)c1ccc(cc1)F
InChI InChI=1S/C36H29FN2O4/c37-26-17-15-25(16-18-26)35(40)30-9-1-4-10-31(30)38-32(36(41)42)23-24-13-19-27(20-14-24)43-22-21-39-33-11-5-2-7-28(33)29-8-3-6-12-34(29)39/h1-20,32,38H,21-23H2,(H,41,42)/t32-/m0/s1
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (China (2022))
IUPAC Name Click here for help
(2S)-3-[4-(2-carbazol-9-ylethoxy)phenyl]-2-[2-(4-fluorobenzoyl)anilino]propanoic acid
Synonyms Click here for help
Bilessglu® | CS-038 | CS038
Database Links Click here for help
CAS Registry No. 743438-45-1 (source: PubChem)
ChEMBL Ligand CHEMBL4650349
GtoPdb PubChem SID 473153875
PubChem CID 71402018
Search Google for chemical match using the InChIKey QNLWMPLUWMWDMQ-YTTGMZPUSA-N
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