LH   Click here for help

GtoPdb Ligand ID: 1159

Synonyms: luteinising hormone | luteinizing hormone
Approved drug
LH is an approved drug (FDA (2004))
Compound class: Endogenous peptide in human, mouse or rat
Comment: The approved drug lutropin alfa (INN) is the recombinant form of human LH and is composed of two subunits (α = 92 amino acids, β = 121 amino acids).
Species: Human
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species

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View more information in the IUPHAR Pharmacology Education Project: lh

Classification Click here for help
Compound class Endogenous peptide in human, mouse or rat
Ligand families/groups Glycoprotein hormones
Approved drug? Yes. FDA (2004)
International Nonproprietary Names Click here for help
INN number INN
7047 lutropin alfa
Synonyms Click here for help
luteinising hormone | luteinizing hormone
Gene/Precursor Click here for help
Gene symbol Gene name Species Precursor protein name Synonyms
CGA glycoprotein hormones, alpha polypeptide Human glycoprotein hormones alpha chain chorionic gonadotropin, alpha polypeptide, follicle-stimulating hormone alpha subunit, FSHA, glycoprotein hormones alpha chain, GPHa, GPHA1, HCG, LHA, luteinizing hormone alpha chain, lutropin alpha chain, thyroid-stimulating hormone alpha chain, TSHA
LHB luteinizing hormone subunit beta Human lutropin subunit beta precursor CGB4, hLHB, interstitial cell stimulating hormone, beta chain, LSH-B, luteinizing hormone beta polypeptide, luteinizing hormone beta subunit, lutropin, beta chain
Database Links Click here for help
Specialist databases
GPCRdb Ligand LH
Other databases
ChEMBL Ligand CHEMBL1201419
DrugBank Ligand DB00044
Ensembl Gene ENSG00000104826 (Hs), ENSG00000135346 (Hs)
GtoPdb PubChem SID 135651804
Human Protein Atlas ENSG00000104826 (Hs), ENSG00000135346 (Hs)
Search PubMed clinical trials lutropin alfa
Search PubMed titles lutropin alfa
Search PubMed titles/abstracts lutropin alfa
UniProtKB P01229 (Hs), P01215 (Hs)
Wikipedia Luteinising_hormone