amodiaquine   Click here for help

GtoPdb Ligand ID: 10018

Synonyms: Alphaquine® | Amdaquine® | Amoquin® | Camoquin® | Flavoquine®
Approved drug PDB Ligand Antimalarial Ligand
amodiaquine is an approved drug
Compound class: Synthetic organic
Comment: Amodiaquine is a 4-aminoquinoline antimalarial compound related to chloroquine.

The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY.

amodiaquine is commercially available from our sponsors

2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 6
Topological polar surface area 48.39
Molecular weight 355.15
XLogP 4.15
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES CCN(Cc1cc(ccc1O)Nc1ccnc2c1ccc(c2)Cl)CC
Isomeric SMILES CCN(Cc1cc(ccc1O)Nc1ccnc2c1ccc(c2)Cl)CC
InChI InChI=1S/C20H22ClN3O/c1-3-24(4-2)13-14-11-16(6-8-20(14)25)23-18-9-10-22-19-12-15(21)5-7-17(18)19/h5-12,25H,3-4,13H2,1-2H3,(H,22,23)
InChI Key OVCDSSHSILBFBN-UHFFFAOYSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Classification Click here for help
Compound class Synthetic organic
Ligand families/groups Antimalarial ligands
Approved drug? Yes.
WHO Essential Medicine WHO Essential Medicines List (EML) (23rd List, 2023). Access PDF version.
Click to view more information about the WHO Model Lists of Essential Medicines.
IUPAC Name Click here for help
4-[(7-chloroquinolin-4-yl)amino]-2-(diethylaminomethyl)phenol
International Nonproprietary Names Click here for help
INN number INN
1116 amodiaquine
Synonyms Click here for help
Alphaquine® | Amdaquine® | Amoquin® | Camoquin® | Flavoquine®
Database Links Click here for help
BindingDB Ligand 50041457
CAS Registry No. 86-42-0 (source: PubChem)
ChEMBL Ligand CHEMBL682
DrugBank Ligand DB00613
DrugCentral Ligand 186
GtoPdb PubChem SID 375973208
PubChem CID 2165
RCSB PDB Ligand CQA
Search Google for chemical match using the InChIKey OVCDSSHSILBFBN-UHFFFAOYSA-N
Search Google for chemicals with the same backbone OVCDSSHSILBFBN
Search PubMed clinical trials amodiaquine
Search PubMed titles amodiaquine
Search PubMed titles/abstracts amodiaquine
UniChem Compound Search for chemical match using the InChIKey OVCDSSHSILBFBN-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey OVCDSSHSILBFBN-UHFFFAOYSA-N

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MedChemExpress
Amodiaquine (links to external site)
Cat. No. HY-B1322A