Top ▲

Kv11.2

Click here for help

Target id: 573

Nomenclature: Kv11.2

Family: Voltage-gated potassium channels (Kv)

Contents:

Gene and Protein Information Click here for help
Species TM P Loops AA Chromosomal Location Gene Symbol Gene Name Reference
Human 6 1 994 17q23.3 KCNH6 potassium voltage-gated channel subfamily H member 6
Mouse 6 1 950 11 E1 Kcnh6 potassium voltage-gated channel, subfamily H (eag-related), member 6
Rat 6 1 950 10q32.1 Kcnh6 potassium voltage-gated channel subfamily H member 6
Previous and Unofficial Names Click here for help
erg2 | HERG2 | eag-related protein 2 | ether-a-go-go-related gene potassium channel 2 | ether-a-go-go-related protein 2 | potassium voltage-gated channel, subfamily H (eag-related), member 6 | potassium channel, voltage gated eag related subfamily H, member 6 | potassium voltage-gated channel
Database Links Click here for help
Alphafold Q9H252 (Hs), O54853 (Rn)
CATH/Gene3D 2.60.120.10
Ensembl Gene ENSG00000173826 (Hs), ENSMUSG00000001901 (Mm), ENSRNOG00000008078 (Rn)
Entrez Gene 81033 (Hs), 192775 (Mm), 116745 (Rn)
Human Protein Atlas ENSG00000173826 (Hs)
KEGG Gene hsa:81033 (Hs), mmu:192775 (Mm), rno:116745 (Rn)
OMIM 608168 (Hs)
Pharos Q9H252 (Hs)
RefSeq Nucleotide NM_030779 (Hs), NM_173092 (Hs), NM_001037712 (Mm), NM_053937 (Rn)
RefSeq Protein NP_110406 (Hs), NP_775115 (Hs), NP_001032801 (Mm), NP_446389 (Rn)
UniProtKB Q9H252 (Hs), O54853 (Rn)
Wikipedia KCNH6 (Hs)
Ion Selectivity and Conductance Click here for help
Species:  Rat
Macroscopic current rectification:  Ik
References:  9,11
Voltage Dependence Click here for help
  V0.5 (mV)  τ (msec)  Reference  Cell type  Species 
Activation  -3.5 4.0 9 Xenopus laevis oocyte Rat
Inactivation  - 100.0 9
  V0.5 (mV)  τ (msec)  Reference  Cell type  Species 
Activation  -14.5 7.3 7 CHO cells Human
Inactivation  -85.2 - 7
  V0.5 (mV)  τ (msec)  Reference  Cell type  Species 
Activation  - 428.0 11 CHO cells. Rat
Inactivation  - -
Comments  Data for heteromultimers of Kv11.2 and Kv11.3 [11]
Associated subunits (Human)
minK (KCNE1)

Download all structure-activity data for this target as a CSV file go icon to follow link

Activators
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Concentration range (M) Holding voltage (mV) Reference
NS1643 Small molecule or natural product Click here for species-specific activity table Hs - 4.9 pEC50 - - 1
⤷ pEC50 4.9 [1]
Activator Comments
NS1643: Negative shift of activation curve, slows inactivation. These effects are distinct from those of the same compound on Kv11.1 [1]
Gating inhibitors Click here for help
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Value Parameter Concentration range (M) Holding voltage (mV) Reference
γ-KTx1.7 Peptide Click here for species-specific activity table Hs - 8.8 pKd - - 8
⤷ pKd 8.8 [8]
ErgTx-1 Peptide Click here for species-specific activity table Rn - 8.5 pKd - - 9
⤷ pKd 8.5 [9]
BeKm-1 Peptide Click here for species-specific activity table Rn - 8.1 pKd - - 9
⤷ pKd 8.1 [9]
ErgTx-1 Peptide Click here for species-specific activity table Hs Inhibition 6.7 pKd - - 6
⤷ pKd 6.7 [6]
View species-specific gating inhibitor tables
Gating Inhibitor Comments
For a review of toxin sensitivity among Kv11 channels, see [10]
Channel Blockers
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Concentration range (M) Holding voltage (mV) Reference
E4031 Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Rn - 6.9 pKd - - 9
⤷ pKd 6.9 [9]
Tissue Distribution Click here for help
Transiently expressed in the developing embryonic spinal cord, largely within GABAergic neurons
Species:  Mouse
Technique:  Immunocytochemistry, immunofluorescence
References:  2
Pancreatic islet cells
Species:  Rat
Technique:  quantitative RT-PCR, immunocytochemistry, electrophysiology
References:  5
The celiac ganglia (CG), the superior mesenteric ganglia (SMG), retina
Species:  Rat
Technique:  In situ hybridisation
References:  9
Tissue Distribution Comments
Kv11.1, Kv11.2 and Kv11.3 are broadly expressed in the nervous system [9,12]. In the developing embryonic spinal cord, they regulate nascent spinal motor rhythms [3]. All are expressed in the adult brain in largely overlapping distributions and largely in neuron somata [4].
Physiological Functions Click here for help
Kv11.2 (and Kv11.3) regulate nascent spinal motor rhythms in developing mouse spinal cord
Species:  Mouse
Tissue:  Organotypic slice cultures of spinal cord and dorsal root ganglia (DRG)
References:  3
All Kv11 transcripts are found in pancreatic islet cells and are under differential spatial and circadian regulation
Species:  Rat
Tissue:  Pancreatic Islet cells
References:  5
Biologically Significant Variants Click here for help
Type:  Splice variant
Species:  Human
Description:  Kv11.2 isoform 2
Amino acids:  905
Nucleotide accession:  NM_173092
Protein accession:  NP_775115
Type:  Splice variant
Species:  Human
Description:  Kv11.2 isoform 1
Amino acids:  994
Nucleotide accession:  NM_030779
Protein accession:  NP_110406

References

Show »

1. Elmedyb P, Olesen SP, Grunnet M. (2007) Activation of ERG2 potassium channels by the diphenylurea NS1643. Neuropharmacology, 53 (2): 283-94. [PMID:17610913]

2. Furlan F, Guasti L, Avossa D, Becchetti A, Cilia E, Ballerini L, Arcangeli A. (2005) Interneurons transiently express the ERG K+ channels during development of mouse spinal networks in vitro. Neuroscience, 135 (4): 1179-92. [PMID:16165280]

3. Furlan F, Taccola G, Grandolfo M, Guasti L, Arcangeli A, Nistri A, Ballerini L. (2007) ERG conductance expression modulates the excitability of ventral horn GABAergic interneurons that control rhythmic oscillations in the developing mouse spinal cord. J Neurosci, 27 (4): 919-28. [PMID:17251434]

4. Guasti L, Cilia E, Crociani O, Hofmann G, Polvani S, Becchetti A, Wanke E, Tempia F, Arcangeli A. (2005) Expression pattern of the ether-a-go-go-related (ERG) family proteins in the adult mouse central nervous system: evidence for coassembly of different subunits. J Comp Neurol, 491 (2): 157-74. [PMID:16127690]

5. Mühlbauer E, Bazwinsky I, Wolgast S, Klemenz A, Peschke E. (2007) Circadian changes of ether-a-go-go-related-gene (Erg) potassium channel transcripts in the rat pancreas and beta-cell. Cell Mol Life Sci, 64 (6): 768-80. [PMID:17322986]

6. Müller R, Thiele J, Klages U, Lingens F. (1984) Incorporation of [18O]water into 4-hydroxybenzoic acid in the reaction of 4-chlorobenzoate dehalogenase from pseudomonas spec. CBS 3. Biochem Biophys Res Commun, 124 (1): 178-82. [PMID:6497878]

7. Restano-Cassulini R, Korolkova YV, Diochot S, Gurrola G, Guasti L, Possani LD, Lazdunski M, Grishin EV, Arcangeli A, Wanke E. (2006) Species diversity and peptide toxins blocking selectivity of ether-a-go-go-related gene subfamily K+ channels in the central nervous system. Mol Pharmacol, 69 (5): 1673-83. [PMID:16497878]

8. Restano-Cassulini R, Olamendi-Portugal T, Zamudio F, Becerril B, Possani LD. (2008) Two novel ergtoxins, blockers of K+-channels, purified from the Mexican scorpion Centruroides elegans elegans. Neurochem Res, 33 (8): 1525-33. [PMID:18338253]

9. Shi W, Wymore RS, Wang HS, Pan Z, Cohen IS, McKinnon D, Dixon JE. (1997) Identification of two nervous system-specific members of the erg potassium channel gene family. J Neurosci, 17 (24): 9423-32. [PMID:9390998]

10. Wanke E, Restano-Cassulini R. (2007) Toxins interacting with ether-à-go-go-related gene voltage-dependent potassium channels. Toxicon, 49 (2): 239-48. [PMID:17097705]

11. Wimmers S, Bauer CK, Schwarz JR. (2002) Biophysical properties of heteromultimeric erg K+ channels. Pflugers Arch, 445 (3): 423-30. [PMID:12466946]

12. Wymore RS, Gintant GA, Wymore RT, Dixon JE, McKinnon D, Cohen IS. (1997) Tissue and species distribution of mRNA for the IKr-like K+ channel, erg. Circ Res, 80 (2): 261-8. [PMID:9012748]

Contributors

Show »

How to cite this page