Contents:
- Gene and Protein Information
- Previous and Unofficial Names
- Database Links
- Functional Characteristics
- Ion Selectivity and Conductance
- Voltage Dependence
- Gating Inhibitors
- Channel Blockers
- Tissue Distribution
- Functional Assays
- Physiological Functions
- Physiological Consequences of Altering Gene Expression
- Phenotypes, Alleles and Disease Models
- Biologically Significant Variants
- References
- Contributors
- How to cite this page
Gene and Protein Information  |
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| Species | TM | P Loops | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 6 | 1 | 638 | 12q21.1 | KCNC2 | potassium voltage-gated channel subfamily C member 2 | 4 |
| Mouse | 6 | 1 | 642 | 10 60.3 cM | Kcnc2 | potassium voltage gated channel, Shaw-related subfamily, member 2 | 4 |
| Rat | 6 | 1 | 638 | 7q22 | Kcnc2 | potassium voltage-gated channel subfamily C member 2 | 10 |
| Previous and Unofficial Names |
| Raw1 | potassium voltage-gated channel subfamily C member 2 | potassium voltage-gated channel, Shaw-related subfamily, member 2 | potassium channel, voltage gated Shaw related subfamily C, member 2 | potassium channel, voltage gated Shaw-related subfamily C, member 2 | potassium voltage gated channel |
| Database Links |
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| Alphafold | Q96PR1 (Hs), Q14B80 (Mm), P22462 (Rn) |
| ChEMBL Target | CHEMBL2363009 (Hs) |
| DrugBank Target | Q96PR1 (Hs) |
| Ensembl Gene | ENSG00000166006 (Hs), ENSMUSG00000035681 (Mm), ENSRNOG00000004077 (Rn) |
| Entrez Gene | 3747 (Hs), 268345 (Mm), 246153 (Rn) |
| Human Protein Atlas | ENSG00000166006 (Hs) |
| KEGG Gene | hsa:3747 (Hs), mmu:268345 (Mm), rno:246153 (Rn) |
| OMIM | 176256 (Hs) |
| Pharos | Q96PR1 (Hs) |
| RefSeq Nucleotide | NM_139136 (Hs), NM_153748 (Hs), NM_139137 (Hs), NM_001025581 (Mm), NM_139216 (Rn), NM_139217 (Rn) |
| RefSeq Protein | NP_715624 (Hs), NP_631875 (Hs), NP_631874 (Hs), NP_001020752 (Mm), NP_631963 (Rn), NP_631962 (Rn) |
| UniProtKB | Q96PR1 (Hs), Q14B80 (Mm), P22462 (Rn) |
| Wikipedia | KCNC2 (Hs) |
| Functional Characteristics |
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| KV | |
| Ion Selectivity and Conductance |
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| Voltage Dependence |
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Download all structure-activity data for this target as a CSV file 
| Gating Inhibitor Comments | ||
| Sea Anemone Toxin BDS-I and BDS-II: At +40 mV, 500 nM BDS-I inhibited rat Kv3.2 by 48.1 ± 4.5% (n = 5), 500 nM BDS-II inhibited Kv3.2 by 52.5 ± 3.7% (n = 4) [25] Alanine substitution mutagenesis around the S3b and S4 segments of Kv3.2 revealed that BDS acts via voltage-sensing domains. [25] |
| Channel Blockers | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| View species-specific channel blocker tables | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Channel Blocker Comments | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 3-isobutyl-1-methylxanthine (IBMX) inhibition in rats [7], D-NONOate caused reversible inhibition in rats, 8-bromo-cGMP also inhibited Kv3.2 currents reversibly (inhibition of 30.49 ± 14.8% from control at +20 mV) [13] | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Tissue Distribution
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| Functional Assays
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| Physiological Functions
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| Physiological Consequences of Altering Gene Expression
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| Phenotypes, Alleles and Disease Models
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| Biologically Significant Variants
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| Biologically Significant Variant Comments | ||||||||||||||
| Alternative splicing of Kv3 genes is involved in channel localisation [14]. |
References
1. Chow A, Erisir A, Farb C, Nadal MS, Ozaita A, Lau D, Welker E, Rudy B. (1999) K(+) channel expression distinguishes subpopulations of parvalbumin- and somatostatin-containing neocortical interneurons. J Neurosci, 19 (21): 9332-45. [PMID:10531438]
2. Erisir A, Lau D, Rudy B, Leonard CS. (1999) Function of specific K(+) channels in sustained high-frequency firing of fast-spiking neocortical interneurons. J Neurophysiol, 82 (5): 2476-89. [PMID:10561420]
3. Goldberg EM, Watanabe S, Chang SY, Joho RH, Huang ZJ, Leonard CS, Rudy B. (2005) Specific functions of synaptically localized potassium channels in synaptic transmission at the neocortical GABAergic fast-spiking cell synapse. J Neurosci, 25 (21): 5230-5. [PMID:15917463]
4. Haas M, Ward DC, Lee J, Roses AD, Clarke V, D'Eustachio P, Lau D, Vega-Saenz de Miera E, Rudy B. (1993) Localization of Shaw-related K+ channel genes on mouse and human chromosomes. Mamm Genome, 4 (12): 711-5. [PMID:8111118]
5. Itri JN, Michel S, Vansteensel MJ, Meijer JH, Colwell CS. (2005) Fast delayed rectifier potassium current is required for circadian neural activity. Nat Neurosci, 8 (5): 650-6. [PMID:15852012]
6. Lau D, Vega-Saenz de Miera EC, Contreras D, Ozaita A, Harvey M, Chow A, Noebels JL, Paylor R, Morgan JI, Leonard CS, Rudy B. (2000) Impaired fast-spiking, suppressed cortical inhibition, and increased susceptibility to seizures in mice lacking Kv3.2 K+ channel proteins. J Neurosci, 20 (24): 9071-85. [PMID:11124984]
7. Lien CC, Martina M, Schultz JH, Ehmke H, Jonas P. (2002) Gating, modulation and subunit composition of voltage-gated K(+) channels in dendritic inhibitory interneurones of rat hippocampus. J Physiol (Lond.), 538 (Pt 2): 405-19. [PMID:11790809]
8. Luneau C, Wiedmann R, Smith JS, Williams JB. (1991) Shaw-like rat brain potassium channel cDNA's with divergent 3' ends. FEBS Lett, 288 (1-2): 163-7. [PMID:1879548]
9. Madeja M, Müller V, Musshoff U, Speckmann EJ. (2000) Sensitivity of native and cloned hippocampal delayed-rectifier potassium channels to verapamil. Neuropharmacology, 39 (2): 202-10. [PMID:10670415]
10. McCormack T, Vega-Saenz de Miera EC, Rudy B. (1990) Molecular cloning of a member of a third class of Shaker-family K+ channel genes in mammals. Proc Natl Acad Sci USA, 87 (13): 5227-31. [PMID:2367536]
11. McDonald AJ, Mascagni F. (2006) Differential expression of Kv3.1b and Kv3.2 potassium channel subunits in interneurons of the basolateral amygdala. Neuroscience, 138 (2): 537-47. [PMID:16413129]
12. Moreno H, Kentros C, Bueno E, Weiser M, Hernandez A, Vega-Saenz de Miera E, Ponce A, Thornhill W, Rudy B. (1995) Thalamocortical projections have a K+ channel that is phosphorylated and modulated by cAMP-dependent protein kinase. J Neurosci, 15 (8): 5486-501. [PMID:7643197]
13. Moreno H, Vega-Saenz de Miera E, Nadal MS, Amarillo Y, Rudy B. (2001) Modulation of Kv3 potassium channels expressed in CHO cells by a nitric oxide-activated phosphatase. J Physiol (Lond.), 530 (Pt 3): 345-58. [PMID:11281123]
14. Ponce A, Vega-Saenz de Miera E, Kentros C, Moreno H, Thornhill B, Rudy B. (1997) K+ channel subunit isoforms with divergent carboxy-terminal sequences carry distinct membrane targeting signals. J Membr Biol, 159 (2): 149-59. [PMID:9307441]
15. Roe MW, Worley 3rd JF, Mittal AA, Kuznetsov A, DasGupta S, Mertz RJ, Witherspoon 3rd SM, Blair N, Lancaster ME, McIntyre MS et al.. (1996) Expression and function of pancreatic beta-cell delayed rectifier K+ channels. Role in stimulus-secretion coupling. J Biol Chem, 271 (50): 32241-6. [PMID:8943282]
16. Rudy B, Chow A, Lau D, Amarillo Y, Ozaita A, Saganich M, Moreno H, Nadal MS, Hernandez-Pineda R, Hernandez-Cruz A et al.. (1999) Contributions of Kv3 channels to neuronal excitability. Ann N Y Acad Sci, 868: 304-43. [PMID:10414303]
17. Smith-Maxwell CJ, Ledwell JL, Aldrich RW. (1998) Role of the S4 in cooperativity of voltage-dependent potassium channel activation. J Gen Physiol, 111 (3): 399-420. [PMID:9482708]
18. Sobko A, Peretz A, Shirihai O, Etkin S, Cherepanova V, Dagan D, Attali B. (1998) Heteromultimeric delayed-rectifier K+ channels in schwann cells: developmental expression and role in cell proliferation. J Neurosci, 18 (24): 10398-408. [PMID:9852577]
19. Song ZM, Hu J, Rudy B, Redman SJ. (2006) Developmental changes in the expression of calbindin and potassium-channel subunits Kv3.1b and Kv3.2 in mouse Renshaw cells. Neuroscience, 139 (2): 531-8. [PMID:16460880]
20. Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF et al.. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci USA, 99 (26): 16899-903. [PMID:12477932]
21. Tansey EP, Chow A, Rudy B, McBain CJ. (2002) Developmental expression of potassium-channel subunit Kv3.2 within subpopulations of mouse hippocampal inhibitory interneurons. Hippocampus, 12 (2): 137-48. [PMID:12000114]
22. Weiser M, Vega-Saenz de Miera E, Kentros C, Moreno H, Franzen L, Hillman D, Baker H, Rudy B. (1994) Differential expression of Shaw-related K+ channels in the rat central nervous system. J Neurosci, 14 (3 Pt 1): 949-72. [PMID:8120636]
23. Xu C, Lu Y, Tang G, Wang R. (1999) Expression of voltage-dependent K(+) channel genes in mesenteric artery smooth muscle cells. Am J Physiol, 277 (5): G1055-63. [PMID:10564112]
24. Yan L, Herrington J, Goldberg E, Dulski PM, Bugianesi RM, Slaughter RS, Banerjee P, Brochu RM, Priest BT, Kaczorowski GJ et al.. (2005) Stichodactyla helianthus peptide, a pharmacological tool for studying Kv3.2 channels. Mol Pharmacol, 67 (5): 1513-21. [PMID:15709110]
25. Yeung SY, Thompson D, Wang Z, Fedida D, Robertson B. (2005) Modulation of Kv3 subfamily potassium currents by the sea anemone toxin BDS: significance for CNS and biophysical studies. J Neurosci, 25 (38): 8735-45. [PMID:16177043]
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