GABA<sub>A</sub> receptor π subunit | GABA<sub>A</sub> receptors | IUPHAR/MMV Guide to MALARIA PHARMACOLOGY

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GABAA receptor π subunit

Target id: 419

Nomenclature: GABAA receptor π subunit

Family: GABAA receptors

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 4 440 5q33-q34 GABRP gamma-aminobutyric acid type A receptor subunit pi 3
Mouse 4 440 11 A4 Gabrp gamma-aminobutyric acid (GABA) A receptor, pi 4
Rat 4 440 10q12 Gabrp gamma-aminobutyric acid type A receptor subunit pi 3
Previous and Unofficial Names
GABA(A) receptor subunit pi | gamma-aminobutyric acid (GABA-A) receptor, pi | gamma-aminobutyric acid (GABA) A receptor | gamma-aminobutyric acid type A receptor pi subunit
Database Links
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
RefSeq Nucleotide
RefSeq Protein
Natural/Endogenous Ligands

Download all structure-activity data for this target as a CSV file

Channel Blockers
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Use-dependent Value Parameter Concentration range (M) Voltage-dependent (mV) Reference
picrotoxin Hs - no - - - no

Not voltage dependent
TBPS Hs - no - - - no

Not voltage dependent
Tissue Distribution
Human tetracarcinoma NT-2 cells and differentiated NT-2N cells
Species:  Human
Technique:  RT-PCR
References:  6
Uterus, lung, thymus, prostate, small intestine, ovaries, placenta
Species:  Human
Technique:  Northern Blot
References:  3
Alevolar epithelial type II cells
Species:  Human
Technique:  RT-PCR and in situ hybridisation.
References:  1
Species:  Rat
Technique:  RNase protection assay, RT-PCR.
References:  2
Gene Expression and Pathophysiology
The π subunit is overexpressed in pancreatic adenocarcinomas
Tissue or cell type:  pancreas
Pathophysiology:  adenocarcinoma
Species:  Human
References:  5


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1. Chen Z, Jin N, Narasaraju T, Chen J, McFarland LR, Scott M, Liu L. (2004) Identification of two novel markers for alveolar epithelial type I and II cells. Biochem. Biophys. Res. Commun., 319 (3): 774-80. [PMID:15184050]

2. Fujii E, Mellon SH. (2001) Regulation of uterine gamma-aminobutyric acid(A) receptor subunit expression throughout pregnancy. Endocrinology, 142 (5): 1770-7. [PMID:11316740]

3. Hedblom E, Kirkness EF. (1997) A novel class of GABAA receptor subunit in tissues of the reproductive system. J. Biol. Chem., 272 (24): 15346-50. [PMID:9182563]

4. Hood HM, Metten P, Crabbe JC, Buck KJ. (2006) Fine mapping of a sedative-hypnotic drug withdrawal locus on mouse chromosome 11. Genes Brain Behav., 5 (1): 1-10. [PMID:16436183]

5. Johnson SK, Haun RS. (2005) The gamma-aminobutyric acid A receptor pi subunit is overexpressed in pancreatic adenocarcinomas. JOP, 6 (2): 136-42. [PMID:15767729]

6. Neelands TR, Zhang J, Macdonald RL. (1999) GABA(A) receptors expressed in undifferentiated human teratocarcinoma NT2 cells differ from those expressed by differentiated NT2-N cells. J. Neurosci., 19 (16): 7057-65. [PMID:10436060]


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