Top ▲

GABAA receptor θ subunit

Click here for help

Target id: 418

Nomenclature: GABAA receptor θ subunit

Family: GABAA receptors

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 3 632 Xq28 GABRQ gamma-aminobutyric acid type A receptor subunit theta 1
Mouse 3 638 X A6 Gabrq gamma-aminobutyric acid type A receptor subunit theta 3
Rat 4 635 Xq37 Gabrq gamma-aminobutyric acid type A receptor subunit theta 3
Previous and Unofficial Names Click here for help
gamma-aminobutyric acid receptor subunit theta | gamma-aminobutyric acid (GABA) A receptor, theta | gamma-aminobutyric acid (GABA) A receptor, subunit theta | gamma-aminobutyric acid (GABA) A receptor | gamma-aminobutyric acid type A receptor theta subunit
Database Links Click here for help
Alphafold Q9UN88 (Hs), Q9JLF1 (Mm)
CATH/Gene3D 2.70.170.10
ChEMBL Target CHEMBL3885575 (Hs), CHEMBL2094133 (Mm)
DrugBank Target Q9UN88 (Hs), Q9UN88 (Hs)
Ensembl Gene ENSG00000268089 (Hs), ENSMUSG00000031344 (Mm), ENSRNOG00000053402 (Rn)
Entrez Gene 55879 (Hs), 57249 (Mm), 65187 (Rn)
Human Protein Atlas ENSG00000268089 (Hs)
KEGG Gene hsa:55879 (Hs), mmu:57249 (Mm), rno:65187 (Rn)
OMIM 300349 (Hs)
Pharos Q9UN88 (Hs)
RefSeq Nucleotide NM_018558 (Hs), NM_020488 (Mm), NM_031733 (Rn)
RefSeq Protein NP_061028 (Hs), NP_065234 (Mm), NP_113921 (Rn)
UniProtKB Q9UN88 (Hs), Q9JLF1 (Mm)
Wikipedia GABRQ (Hs)
Natural/Endogenous Ligands Click here for help
GABA

Download all structure-activity data for this target as a CSV file go icon to follow link

Channel Blockers
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Use-dependent Value Parameter Concentration range (M) Voltage-dependent (mV) Reference
picrotoxin Small molecule or natural product Click here for species-specific activity table Hs - no - - - no
⤷
Not voltage dependent
TBPS Small molecule or natural product Click here for species-specific activity table Hs - no - - - no
⤷
Not voltage dependent
Tissue Distribution Click here for help
Substantia nigra pars compacta, locus coeruleus
Species:  Human
Technique:  In situ hybridization and immunohistochemistry
References:  1
Locus coeruleus, centromedial thalamic region, hypothalamus (dorsomedial and ventromedial regions)
Species:  Rat
Technique:  In situ hybridisation
References:  3
Septum (ventral and intermediate nucleus), bed nuclei and the stria terminalis, amygdala (medial and central nuclei), dentate gyrus, preoptic areas, hypothalamus, thalamus, lateral geniculate nucleus, raphe nuclei, locus coeruleus
Species:  Rat
Technique:  In situ hybridisation
References:  2
Cerebral cortex (cingulate and piriform regions), olfactory tract, nucleus accumbens, hypothalamus (anterior and mammiliary body), amygdala, hippocampus, substantia nigra, pineal gland, pons, dorsal raphe, central grey
Species:  Monkey
Technique:  In situ hybridisation
References:  1
Hypothalamus, cortical pyramidal neurones, substantia nigra pars compacta and associated neurites of the pars reticulata, ventral and lateral tegmental areas, locus coeruleus, recticular pontine nuclei, dorsal raphe
Species:  Monkey
Technique:  Immunohistochemistry
References:  1

References

Show »

1. Bonnert TP, McKernan RM, Farrar S, le Bourdellès B, Heavens RP, Smith DW, Hewson L, Rigby MR, Sirinathsinghji DJ, Brown N, Wafford KA, Whiting PJ. (1999) theta, a novel gamma-aminobutyric acid type A receptor subunit. Proc Natl Acad Sci USA, 96 (17): 9891-6. [PMID:10449790]

2. Moragues N, Ciofi P, Tramu G, Garret M. (2002) Localisation of GABA(A) receptor epsilon-subunit in cholinergic and aminergic neurones and evidence for co-distribution with the theta-subunit in rat brain. Neuroscience, 111 (3): 657-69. [PMID:12031352]

3. Sinkkonen ST, Hanna MC, Kirkness EF, Korpi ER. (2000) GABA(A) receptor epsilon and theta subunits display unusual structural variation between species and are enriched in the rat locus ceruleus. J Neurosci, 20 (10): 3588-95. [PMID:10804200]

Contributors

Show »

How to cite this page