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Target id: 377

Nomenclature: 5-HT3E

Family: 5-HT3 receptors

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 4 456 3q27.1 HTR3E 5-hydroxytryptamine receptor 3E 2-4
Previous and Unofficial Names Click here for help
HTR3C1long | 5-hydroxytryptamine (serotonin) receptor 3E, ionotropic
Database Links Click here for help
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
RefSeq Nucleotide
RefSeq Protein
Natural/Endogenous Ligands Click here for help
Tissue Distribution Click here for help
Colon, intestine.
Species:  Human
Technique:  RT-PCR
References:  3
Small intestine >> spinal cord and retina.
Species:  Human
Technique:  RT-PCR
References:  2
Essentially ubiquitous, relatively high levels of expression in dorsal root ganglia, pituitary, brain, kidney and thyroid
Species:  Human
Technique:  RT-PCR
References:  1
Biologically Significant Variants Click here for help
Type:  Splice variant
Species:  Human
Description:  Canonical isoform.
Amino acids:  471
Nucleotide accession: 
Protein accession: 
References:  2-3
Type:  Splice variant
Species:  Human
Description:  The human 5-HT3E subunit occurs as a variant that has unofficially been termed 5-HT3E(A) (or HTR3C1short).
Amino acids:  456
Nucleotide accession: 
Protein accession: 
References:  4
General Comments
The 5-HT3E subunit is absent from the rodent genome [1-3]. The human 5-HT3E subunit does not function as a homomer [1,4]. Co-expression with the 5-HT3A subunit has been found to mandatory for the expression of the 5-HT3E subunit at the cell surface in one study [4], but not in a second [1]. Co-assembly of the 5-HT3A and 5-HT3E subunits when heterologously expressed in HEK-293 cells has been demonstrated by immunoprecipitation [4]. Co-expression of the 5-HT3A and 5-HT3E subunits does not alter the potency of agonists and antagonists observed for homopentameric 5-HT3A receptors [1,4].


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1. Holbrook JD, Gill CH, Zebda N, Spencer JP, Leyland R, Rance KH, Trinh H, Balmer G, Kelly FM, Yusaf SP et al.. (2009) Characterisation of 5-HT3C, 5-HT3D and 5-HT3E receptor subunits: evolution, distribution and function. J Neurochem, 108 (2): 384-96. [PMID:19012743]

2. Karnovsky AM, Gotow LF, McKinley DD, Piechan JL, Ruble CL, Mills CJ, Schellin KA, Slightom JL, Fitzgerald LR, Benjamin CW et al.. (2003) A cluster of novel serotonin receptor 3-like genes on human chromosome 3. Gene, 319: 137-48. [PMID:14597179]

3. Niesler B, Frank B, Kapeller J, Rappold GA. (2003) Cloning, physical mapping and expression analysis of the human 5-HT3 serotonin receptor-like genes HTR3C, HTR3D and HTR3E. Gene, 310: 101-11. [PMID:12801637]

4. Niesler B, Walstab J, Combrink S, Möller D, Kapeller J, Rietdorf J, Bönisch H, Göthert M, Rappold G, Brüss M. (2007) Characterization of the novel human serotonin receptor subunits 5-HT3C,5-HT3D, and 5-HT3E. Mol Pharmacol, 72 (1): 8-17. [PMID:17392525]


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