Top ▲


Click here for help

Target id: 375

Nomenclature: 5-HT3C

Family: 5-HT3 receptors

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 4 447 3q27.1 HTR3C 5-hydroxytryptamine receptor 3C 3-5
Previous and Unofficial Names Click here for help
5-hydroxytryptamine (serotonin) receptor 3C, ionotropic
Database Links Click here for help
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
RefSeq Nucleotide
RefSeq Protein
Natural/Endogenous Ligands Click here for help
Tissue Distribution Click here for help
Brain, colon, intestine, lung, muscle, stomach.
Species:  Human
Technique:  RT-PCR
References:  4
Dorsal root ganglia, lung, duodenum, cecum, brain
Species:  Human
Technique:  RT-PCR
References:  2
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Emesis
References:  1
Click column headers to sort
Type Species Amino acid change Nucleotide change Description Reference
Missense Human K163N 1
General Comments
The HTR3C gene is absent from the rodent genome [2-4]. The human 5-HT3C subunit does not function as a homomer [2,5]. Co-expression with the 5-HT3A subunit has been found to mandatory for the expression of the 5-HT3C subunit at the cell surface in one study [5], but not in a second [2]. Co-assembly of the 5-HT3A and 5-HT3C subunits when heterologously expressed in HEK-293 cells has been demonstrated by immunoprecipitation [5]. Co-expression of the 5-HT3C and 5-HT3A subunits does not alter the potency of agonists and antagonists observed for homopentameric 5-HT3A receptors [2,5].


Show »

1. Fasching PA, Kollmannsberger B, Strissel PL, Niesler B, Engel J, Kreis H, Lux MP, Weihbrecht S, Lausen B, Bani MR, Beckmann MW, Strick R. (2008) Polymorphisms in the novel serotonin receptor subunit gene HTR3C show different risks for acute chemotherapy-induced vomiting after anthracycline chemotherapy. J Cancer Res Clin Oncol, 134 (10): 1079-86. [PMID:18389280]

2. Holbrook JD, Gill CH, Zebda N, Spencer JP, Leyland R, Rance KH, Trinh H, Balmer G, Kelly FM, Yusaf SP et al.. (2009) Characterisation of 5-HT3C, 5-HT3D and 5-HT3E receptor subunits: evolution, distribution and function. J Neurochem, 108 (2): 384-96. [PMID:19012743]

3. Karnovsky AM, Gotow LF, McKinley DD, Piechan JL, Ruble CL, Mills CJ, Schellin KA, Slightom JL, Fitzgerald LR, Benjamin CW et al.. (2003) A cluster of novel serotonin receptor 3-like genes on human chromosome 3. Gene, 319: 137-48. [PMID:14597179]

4. Niesler B, Frank B, Kapeller J, Rappold GA. (2003) Cloning, physical mapping and expression analysis of the human 5-HT3 serotonin receptor-like genes HTR3C, HTR3D and HTR3E. Gene, 310: 101-11. [PMID:12801637]

5. Niesler B, Walstab J, Combrink S, Möller D, Kapeller J, Rietdorf J, Bönisch H, Göthert M, Rappold G, Brüss M. (2007) Characterization of the novel human serotonin receptor subunits 5-HT3C,5-HT3D, and 5-HT3E. Mol Pharmacol, 72 (1): 8-17. [PMID:17392525]


Show »

How to cite this page