Plasmodium falciparum Niemann-Pick type C1-related protein | Antimalarial targets | IUPHAR/MMV Guide to MALARIA PHARMACOLOGY

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Plasmodium falciparum Niemann-Pick type C1-related protein

Target id: 3107

Nomenclature: Plasmodium falciparum Niemann-Pick type C1-related protein

Abbreviated Name: PfNCR1

Family: Antimalarial targets

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Plasmodium falciparum 3D7 - 1470 NCR1 Niemann-Pick type C1-related protein
Database Links
PlasmoDB
UniProtKB
Malaria Pharmacology Comments
The P. falciparum Niemann-Pick Type C1-Related protein (PfNCR1) localizes to the parasite plasma membrane and contains sequence motifs found in Niemann-Pick C1 (NPC1) proteins [1-2].

References

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1. Bhatnagar S, Nicklas S, Morrisey JM, Goldberg DE, Vaidya AB. (2019) Diverse Chemical Compounds Target Plasmodium falciparum Plasma Membrane Lipid Homeostasis. ACS Infect Dis, 5 (4): 550-558. [PMID:30638365]

2. Istvan ES, Das S, Bhatnagar S, Beck JR, Owen E, Llinas M, Ganesan SM, Niles JC, Winzeler E, Vaidya AB et al.. (2019) Plasmodium Niemann-Pick type C1-related protein is a druggable target required for parasite membrane homeostasis. Elife, 8. [PMID:30888318]

How to cite this page

Antimalarial targets: Plasmodium falciparum Niemann-Pick type C1-related protein. Last modified on 05/03/2020. Accessed on 26/09/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=3107.