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Transporters (Plasmodium spp.)

Overview

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To survive and replicate during the intraerythrocytic lifecycle stages, the malaria parasite uses a range of transport processes to take up nutrients, export waste products, and maintain tight regulation over its own internal ionic environment [1]. Plasmodium membrane transport proteins are candidate targets for antimalarial drug discovery but have also been shown to play a role in the development of drug resistance.

Targets

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PfATP4 (Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase) C Show summary » More detailed page go icon to follow link

Plasmodium falciparum V-type proton ATPase subunit D C Show summary » More detailed page go icon to follow link

PfCARL (Plasmodium falciparum cyclic amine resistance locus protein) C Show summary » More detailed page go icon to follow link

PfHT1 (Plasmodium falciparum hexose transporter) C Show summary » More detailed page go icon to follow link

PfNCR1 (Plasmodium falciparum Niemann-Pick type C1-related protein) C Show summary » More detailed page go icon to follow link

References

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How to cite this family page

Database page citation:

Transporters (Plasmodium spp.). Accessed on 02/07/2022. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1064.

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Introduction and Other Protein Targets. Br J Pharmacol. 178 Suppl 1:S1-S26.