Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Plasmodium falciparum 3D7	-	1470		NCR1	Niemann-Pick type C1-related protein

Previous and Unofficial Names

NCR1 | Pf3D7_01_v3:303,437..311,928(-) | PFA0375c

Database Links
Alphafold	Q8I266 (Pf3D7)
PlasmoDB	PF3D7_0107500 (Pf3D7)
UniProtKB	Q8I266 (Pf3D7)

Whole Organism Assay Data Linked to This Target
Key to terms and symbols		Click column headers to sort
Ligand Sp. Assay description Type Action Value Parameter Reference MMV009108 Pf3D7 Plasmodium falciparum 3D7 P. falciparum strain 3D7 (Pf3D7) was derived from isolate NF54 by limiting dilution. The complete genome of Pf3D7 has been sequenced (GenBank: LN999946.1). Pf3D7 can be obtained from the European Malaria Reagent Repository or the Malaria Research and Reference Reagent Resource Center (MR4) and is sensitive to a panel of antimalarial compounds including chloroquine and pyrimethamine. ✖ Parasite growth inhibition assay - - 6.3 pEC50 2 ⤷ pEC50 6.3 (EC50 4.54x10-7 M) [2] Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)

Malaria Pharmacology Comments

The P. falciparum Niemann-Pick type C1-related protein (PfNCR1) localizes to the parasite plasma membrane and contains sequence motifs found in Niemann-Pick C1 (NPC1) proteins [2]. A number of structurally diverse compounds have validated PfNCR1 as a chemically tractable antimalarial drug target that has an essential role in maintaining membrane lipid composition during the asexual blood stage of the parasite lifecycle [1-2].