Plasmodium falciparum V-type proton ATPase | Antimalarial targets | IUPHAR/MMV Guide to MALARIA PHARMACOLOGY

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Plasmodium falciparum V-type proton ATPase

Target id: 3078

Nomenclature: Plasmodium falciparum V-type proton ATPase

Family: Antimalarial targets

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Plasmodium falciparum 3D7 - 247 PF3D7_1341900 V-type proton ATPase subunit D, putative
Previous and Unofficial Names
Plasmodium falciparum V-type H+ ATPase
Database Links
UniProtKB
Whole Organism Assay Data Linked to This Target
Key to terms and symbols Click column headers to sort
Ligand Sp. Assay description Type Action Value Parameter Reference
MMV253 PfNF54 Parasite growth inhibition assay - - 8.1 pIC50 1
pIC50 8.1 (IC50 9x10-9 M) SYBR Green assay [1]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
MMV253 PfK1 Parasite growth inhibition assay - - 7.8 pIC50 1
pIC50 7.8 (IC50 1.5x10-8 M) SYBR Green assay [1]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Malaria Pharmacology Comments
V-type (vacuolar or vesicular proton pump) ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex attached to an integral membrane V0 proton pore complex that transports protons across the plasma membrane to maintain the intracellular pH [2].

References

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1. Hameed P S, Solapure S, Patil V, Henrich PP, Magistrado PA, Bharath S, Murugan K, Viswanath P, Puttur J, Srivastava A et al.. (2015) Triaminopyrimidine is a fast-killing and long-acting antimalarial clinical candidate. Nat Commun, 6: 6715. [PMID:25823686]

2. Marchesini N, Vieira M, Luo S, Moreno SN, Docampo R. (2005) A malaria parasite-encoded vacuolar H(+)-ATPase is targeted to the host erythrocyte. J. Biol. Chem., 280 (44): 36841-7. [PMID:16135514]

How to cite this page

Antimalarial targets: Plasmodium falciparum V-type proton ATPase. Last modified on 17/06/2019. Accessed on 21/10/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=3078.