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Plasmodium falciparum V-type proton ATPase subunit D

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Target id: 3078

Nomenclature: Plasmodium falciparum V-type proton ATPase subunit D

Family: Transporters (Plasmodium spp.)

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Plasmodium falciparum 3D7 - 247 PF3D7_1341900 V-type proton ATPase subunit D, putative
Previous and Unofficial Names Click here for help
Plasmodium falciparum V-type H+ ATPase | PF13_0227
Database Links Click here for help
Alphafold
PlasmoDB
UniProtKB
Whole Organism Assay Data Linked to This Target
Key to terms and symbols Click column headers to sort
Ligand Sp. Assay description Type Action Value Parameter Reference
MMV253 Small molecule or natural product Guide to Malaria Pharmacology Ligand PfNF54 Parasite growth inhibition assay - - 8.1 pIC50 1
pIC50 8.1 (IC50 9x10-9 M) SYBR Green assay [1]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
MMV253 Small molecule or natural product Guide to Malaria Pharmacology Ligand PfK1 Parasite growth inhibition assay - - 7.8 pIC50 1
pIC50 7.8 (IC50 1.5x10-8 M) SYBR Green assay [1]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Malaria Pharmacology Comments
V-type (vacuolar or vesicular proton pump) ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex attached to an integral membrane V0 proton pore complex that transports protons across the plasma membrane to maintain the intracellular pH [2].

References

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1. Hameed P S, Solapure S, Patil V, Henrich PP, Magistrado PA, Bharath S, Murugan K, Viswanath P, Puttur J, Srivastava A et al.. (2015) Triaminopyrimidine is a fast-killing and long-acting antimalarial clinical candidate. Nat Commun, 6: 6715. [PMID:25823686]

2. Marchesini N, Vieira M, Luo S, Moreno SN, Docampo R. (2005) A malaria parasite-encoded vacuolar H(+)-ATPase is targeted to the host erythrocyte. J Biol Chem, 280 (44): 36841-7. [PMID:16135514]

How to cite this page

Transporters (Plasmodium spp.): Plasmodium falciparum V-type proton ATPase subunit D. Last modified on 12/10/2021. Accessed on 25/06/2022. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=3078.