Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Plasmodium falciparum 3D7	-	247		PF3D7_1341900	V-type proton ATPase subunit D, putative

Previous and Unofficial Names

PF3D7_1341900 | Pf3D7_13_v3:1,649,035..1,651,981(-) | Plasmodium falciparum V-type H+ ATPase | PF13_0227

Database Links
Alphafold	Q8IDS0 (Pf3D7)
PlasmoDB	PF3D7_1341900 (Pf3D7)
UniProtKB	Q8IDS0 (Pf3D7)

Whole Organism Assay Data Linked to This Target
Key to terms and symbols		Click column headers to sort
Ligand Sp. Assay description Type Action Value Parameter Reference sutidiazine PfNF54 Plasmodium falciparum NF54 P. falciparum strain NF54 (PfNF54) was derived from a patient who had never left the Netherlands. PfNF54 can be obtained from the European Malaria Reagent Repository or the Malaria Research and Reference Reagent Resource Center (MR4) and is sensitive to a panel of antimalarial compounds including chloroquine and pyrimethamine. ✖ Parasite growth inhibition assay - - 8.1 pIC50 1 ⤷ pIC50 8.1 (IC50 9x10-9 M) SYBR Green assay [1] Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont) sutidiazine PfK1 Plasmodium falciparum K1 P. falciparum strain K1 (PfK1) was isolated in Kanchanaburi, Thailand in 1979. PfK1 can be obtained from the European Malaria Reagent Repository or the Malaria Research and Reference Reagent Resource Center (MR4) and is reported to be a multidrug-resistant strain. ✖ Parasite growth inhibition assay - - 7.8 pIC50 1 ⤷ pIC50 7.8 (IC50 1.5x10-8 M) SYBR Green assay [1] Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)

Malaria Pharmacology Comments

V-type (vacuolar or vesicular proton pump) ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex attached to an integral membrane V0 proton pore complex that transports protons across the plasma membrane to maintain the intracellular pH [2].