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NADPH oxidase 5

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Target id: 3005

Nomenclature: NADPH oxidase 5

Abbreviated Name: NOX5

Family: NADPH oxidases

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 765 15q23 NOX5 NADPH oxidase 5 2
Gene and Protein Information Comments
There are no rat or mouse orthologues of the human NOX5 gene. Variant 1 (NOX5 gamma, or v3) encodes isoform 1 which is the longest protein product dervived from this gene. Two shorter isoforms are also encoded by NOX5.
Previous and Unofficial Names Click here for help
NADPH oxidase, EF-hand calcium binding domain 5
Database Links Click here for help
Alphafold Q96PH1 (Hs)
ChEMBL Target CHEMBL1926497 (Hs)
Ensembl Gene ENSG00000255346 (Hs)
Entrez Gene 79400 (Hs)
Human Protein Atlas ENSG00000255346 (Hs)
KEGG Gene hsa:79400 (Hs)
OMIM 606572 (Hs)
Pharos Q96PH1 (Hs)
RefSeq Nucleotide NM_024505 (Hs)
RefSeq Protein NP_078781 (Hs)
UniProtKB Q96PH1 (Hs)
Wikipedia NOX5 (Hs)

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
setanaxib Small molecule or natural product Click here for species-specific activity table Immunopharmacology Ligand Hs Inhibition 6.4 pKi 1
⤷ pKi 6.4 (Ki 4.1x10-7 M) [1]
compound 7c [PMID: 22041175] Small molecule or natural product Click here for species-specific activity table Immunopharmacology Ligand Hs Inhibition 6.4 pKi 3
⤷ pKi 6.4 (Ki 4.14x10-7 M) [3]
NSC 780521 Small molecule or natural product Click here for species-specific activity table Hs Inhibition 6.6 pIC50 4
⤷ pIC50 6.6 (IC50 2.29x10-7 M) [4]
Description: Inhibition of PMA-induced superoxide production by UACC-257 cells.
Immuno Process Associations
Immuno Process:  Cytokine production & signalling

References

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1. Aoyama T, Paik YH, Watanabe S, Laleu B, Gaggini F, Fioraso-Cartier L, Molango S, Heitz F, Merlot C, Szyndralewiez C et al.. (2012) Nicotinamide adenine dinucleotide phosphate oxidase in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent. Hepatology, 56 (6): 2316-27. [PMID:22806357]

2. Bánfi B, Molnár G, Maturana A, Steger K, Hegedûs B, Demaurex N, Krause KH. (2001) A Ca(2+)-activated NADPH oxidase in testis, spleen, and lymph nodes. J Biol Chem, 276 (40): 37594-601. [PMID:11483596]

3. Gaggini F, Laleu B, Orchard M, Fioraso-Cartier L, Cagnon L, Houngninou-Molango S, Gradia A, Duboux G, Merlot C, Heitz F et al.. (2011) Design, synthesis and biological activity of original pyrazolo-pyrido-diazepine, -pyrazine and -oxazine dione derivatives as novel dual Nox4/Nox1 inhibitors. Bioorg Med Chem, 19 (23): 6989-99. [PMID:22041175]

4. Lu J, Risbood P, Kane Jr CT, Hossain MT, Anderson L, Hill K, Monks A, Wu Y, Antony S, Juhasz A et al.. (2017) Characterization of potent and selective iodonium-class inhibitors of NADPH oxidases. Biochem Pharmacol, 143: 25-38. [PMID:28709950]

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