NADPH oxidases

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NADPH oxidases

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The two DUOX enzymes were originally identified as participating in the production of hydrogen peroxide as a pre-requisite for thyroid hormone biosynthesis in the thyroid gland [1].
NOX enzymes function to catalyse the reduction of molecular oxygen to superoxide and various other reactive oxygen species (ROS). They are subunits of the NADPH oxidase complex.

Enzymes

DUOX1 (dual oxidase 1) Show summary »« Hide summary More detailed page go icon to follow link

Target Id

3000

Nomenclature

dual oxidase 1

Common abbreviation

DUOX1

Previous and unofficial names

flavoprotein NADPH oxidase | LNOX1 | NADPH thyroid oxidase 1 | NOXEF1 | THOX1

Genes

DUOX1 (Hs), Duox1 (Mm), Duox1 (Rn)

Ensembl ID

ENSG00000137857 (Hs), ENSMUSG00000033268 (Mm), ENSRNOG00000033348 (Rn)

UniProtKB AC

Q9NRD9 (Hs), Q8CIY2 (Rn)

EC number

1.6.3.1
Generation of hydrogen peroxide NAD(P)H + O₂ <=> NAD(P)⁺ + H₂O₂

DUOX2 (dual oxidase 2) Show summary »« Hide summary More detailed page go icon to follow link

Target Id

2999

Nomenclature

dual oxidase 2

Common abbreviation

DUOX2

Previous and unofficial names

Genes

DUOX2 (Hs), Duox2 (Mm), Duox2 (Rn)

Ensembl ID

ENSG00000140279 (Hs), ENSMUSG00000068452 (Mm), ENSRNOG00000017395 (Rn)

UniProtKB AC

Q9NRD8 (Hs), Q8BV64 (Mm), Q9ES45 (Rn)

EC number

1.6.3.1
Generation of hydrogen peroxide NAD(P)H + O₂ <=> NAD(P)⁺ + H₂O₂

NOX1 (NADPH oxidase 1) Show summary »« Hide summary More detailed page go icon to follow link

Target Id	3001
Nomenclature	NADPH oxidase 1
Common abbreviation	NOX1
Previous and unofficial names	GP91-2 \| MOX1 \| NOH1 \| GP91 phox homolog \| NADH/NADPH mitogenic oxidase subunit p65-mox
Genes	NOX1 (Hs), Nox1 (Mm), Nox1 (Rn)
Ensembl ID	ENSG00000007952 (Hs), ENSMUSG00000031257 (Mm), ENSRNOG00000048706 (Rn)
UniProtKB AC	Q9Y5S8 (Hs), Q8CIZ9 (Mm), Q9WV87 (Rn)

NOX2 (cytochrome b-245 beta chain) Show summary »« Hide summary More detailed page go icon to follow link

Target Id	3002
Nomenclature	cytochrome b-245 beta chain
Common abbreviation	NOX2
Previous and unofficial names	cytochrome b-245 \| cytochrome b-245, beta polypeptide \| GP91-PHOX \| NADPH oxidase 2 \| cytochrome b-245, heavy chain
Genes	CYBB (Hs), Cybb (Mm), Cybb (Rn)
Ensembl ID	ENSG00000165168 (Hs), ENSMUSG00000015340 (Mm), ENSRNOG00000003622 (Rn)
UniProtKB AC	P04839 (Hs), Q61093 (Mm)

NOX3 (NADPH oxidase 3) Show summary »« Hide summary More detailed page go icon to follow link

NOX4 (NADPH oxidase 4) Show summary »« Hide summary More detailed page go icon to follow link

NOX5 (NADPH oxidase 5) Show summary »« Hide summary More detailed page go icon to follow link

Target Id	3005
Nomenclature	NADPH oxidase 5
Common abbreviation	NOX5
Previous and unofficial names	NADPH oxidase, EF-hand calcium binding domain 5
Genes	NOX5 (Hs)
Ensembl ID	ENSG00000255346 (Hs)
UniProtKB AC	Q96PH1 (Hs)

References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.