Plasmodium falciparum phenylalanine--tRNA ligase alpha subunit | Antimalarial targets | IUPHAR/MMV Guide to MALARIA PHARMACOLOGY

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Plasmodium falciparum phenylalanine--tRNA ligase alpha subunit

Target id: 2954

Nomenclature: Plasmodium falciparum phenylalanine--tRNA ligase alpha subunit

Abbreviated Name: PfcPheRS

Family: Antimalarial targets

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Plasmodium falciparum 3D7 - 575 cPheRS phenylalanine--tRNA ligase alpha subunit
Previous and Unofficial Names
Pfal cPheRS
Database Links

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Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
BRD3444 Pf3D7 Inhibition 7.3 pIC50 1
pIC50 7.3 (IC50 4.6x10-8 M) [1]
Malaria Pharmacology Comments
The aminoacyl-tRNA synthetases are emerging targets for antimalarial agents [2]. Although sharing a common tRNA esterification catalytic activity, these proteins are structurally diverse and physiologically distinct enzymes. The target described here (PfcPheRS) is unique in that it is the first member of the class whose inhibition results in elimination of blood (asexual and sexual), liver and transmission stage parasites [1].


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1. Kato N, Comer E, Sakata-Kato T, Sharma A, Sharma M, Maetani M, Bastien J, Brancucci NM, Bittker JA, Corey V et al.. (2016) Diversity-oriented synthesis yields novel multistage antimalarial inhibitors. Nature, 538 (7625): 344-349. [PMID:27602946]

2. Manickam Y, Chaturvedi R, Babbar P, Malhotra N, Jain V, Sharma A. (2018) Drug targeting of one or more aminoacyl-tRNA synthetase in the malaria parasite Plasmodium falciparum. Drug Discov. Today, 23 (6): 1233-1240. [PMID:29408369]

How to cite this page

Antimalarial targets: Plasmodium falciparum phenylalanine--tRNA ligase alpha subunit. Last modified on 12/06/2019. Accessed on 25/09/2020. IUPHAR/BPS Guide to PHARMACOLOGY,