Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	1	500	5q35.3	BTNL8	butyrophilin like 8
Gene and Protein Information Comments
Several transcript variants and protein isoforms are predicted from the human gene. We provide details for the longest form (variant 1, isoform 1) here.

Previous and Unofficial Names

BTN9.2 | butyrophilin-like 8

Database Links
Alphafold	Q6UX41 (Hs)
CATH/Gene3D	2.60.40.10
Ensembl Gene	ENSG00000113303 (Hs)
Entrez Gene	79908 (Hs)
Human Protein Atlas	ENSG00000113303 (Hs)
KEGG Gene	hsa:79908 (Hs)
OMIM	615606 (Hs)
Pharos	Q6UX41 (Hs)
RefSeq Nucleotide	NM_024850 (Hs)
RefSeq Protein	NP_079126 (Hs)
UniProtKB	Q6UX41 (Hs)
Wikipedia	BTNL8 (Hs)

Immunopharmacology Comments

BTNL3 and BTNL8 are two proteins expressed on the surface of human gut epithelial cells that are involved in shaping the constitution of gut resident dendritic γδ T cells [2]. γδ T cells in epithelial surfaces play a role in immunosurveillance and hence barrier integrity. Organ-specific expression of butyrophilin and butyrophilin-like proteins appears to be a conserved mechanism utilised by epithelia to shape local T cell compartments. Altered expression of BTNL genes has been associated with intestinal inflammation and colon cancer [3]. Predicted-deleterious variants in BTNL8 have been identified in children presenting with post-COVID-19 multisystem inflammatory syndrome (MIS-C) [1]. It is suggested that these rare variants may predispose to disrupted gut homeostasis and MIS-C-associated enteropathy. This protein contains an immunoglobulin (Ig)-like domain that resembles the antibody variable domain, that has been coined the 'V-set domain'. The genes for all human V-set domain containing proteins are listed in HGNC gene group 590.

Immuno Process Associations

Immuno Process:  Cellular signalling

Immuno Process:  Immune regulation

Immuno Process:  T cell (activation)

Immuno Process:  B cell (activation)