Butyrophilin and butyrophilin-like proteins

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Butyrophilin and butyrophilin-like proteins

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Butyrophilin (BTN) proteins modulate T cell responses to antigen presentation by MHC molecules and cognate αβ T cell receptor (TCR) engagement. Some BTNs mediate interactions between antigen-presenting cells and conventional αβ T cells (as immune checkpoints), and others regulate activity of specific γδ T cell subsets in the maintenance of barrier integrity at mucosal surfaces for example- reviewed in [1].

Targets

butyrophilin like 3 Show summary »« Hide summary More detailed page go icon to follow link

Target Id	2944
Nomenclature	butyrophilin like 3
Previous and unofficial names	BTN9.1
Genes	BTNL3 (Hs)
Ensembl ID	ENSG00000168903 (Hs)
UniProtKB AC	Q6UXE8 (Hs)

butyrophilin like 8 Show summary »« Hide summary More detailed page go icon to follow link

Target Id	2947
Nomenclature	butyrophilin like 8
Previous and unofficial names	BTN9.2 \| butyrophilin-like 8
Genes	BTNL8 (Hs)
Ensembl ID	ENSG00000113303 (Hs)
UniProtKB AC	Q6UX41 (Hs)

butyrophilin subfamily 3 member A1 Show summary »« Hide summary More detailed page go icon to follow link

Target Id	2948
Nomenclature	butyrophilin subfamily 3 member A1
Previous and unofficial names	BT3.1 \| BTN3.1 \| CD277
Genes	BTN3A1 (Hs)
Ensembl ID	ENSG00000026950 (Hs)
UniProtKB AC	O00481 (Hs)

References

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How to cite this family page

Database page citation:

Butyrophilin and butyrophilin-like proteins. Accessed on 04/05/2026. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=966.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Gibb AJ, Kelly E, Mathie AA, Peach CJ, Veale EL, Cidlowski JA, Davenport AP, Fabbro D, Spedding M, Striessnig J, Armstrong JF, Buneman OP, Faccenda E, Harding SD, Southan C, Davies JA et al. (2025) The Concise Guide to PHARMACOLOGY 2025/26: Introduction and Other Protein Targets. Br J Pharmacol. 182: S1-S23.