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Contents:
Gene and Protein Information  |
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| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 1 | 466 | 5q35.3 | BTNL3 | butyrophilin like 3 | 3 |
| Previous and Unofficial Names |
| BTN9.1 |
| Database Links |
|
| Alphafold | Q6UXE8 (Hs) |
| CATH/Gene3D | 2.60.40.10 |
| Ensembl Gene | ENSG00000168903 (Hs) |
| Entrez Gene | 10917 (Hs) |
| Human Protein Atlas | ENSG00000168903 (Hs) |
| KEGG Gene | hsa:10917 (Hs) |
| OMIM | 606192 (Hs) |
| Pharos | Q6UXE8 (Hs) |
| RefSeq Nucleotide | NM_197975 (Hs) |
| RefSeq Protein | NP_932079 (Hs) |
| UniProtKB | Q6UXE8 (Hs) |
| Wikipedia | BTNL3 (Hs) |
| Immunopharmacology Comments |
| BTNL3 and BTNL8 are two proteins expressed on the surface of human gut epithelial cells that are involved in shaping the constitution of gut resident dendritic γδ T cells [1]. γδ T cells in epithelial surfaces play a role in immunosurveillance and hence barrier integrity. Organ-specific expression of butyrophilin and butyrophilin-like proteins appears to be a conserved mechanism utilised by epithelia to shape local T cell compartments. Altered expression of BTNL genes has been associated with intestinal inflammation and colon cancer [2]. This protein contains an immunoglobulin (Ig)-like domain that resembles the antibody variable domain, that has been coined the 'V-set domain'. The genes for all human V-set domain containing proteins are listed in HGNC gene group 590. |
References
1. Di Marco Barros R, Roberts NA, Dart RJ, Vantourout P, Jandke A, Nussbaumer O, Deban L, Cipolat S, Hart R, Iannitto ML et al.. (2016) Epithelia Use Butyrophilin-like Molecules to Shape Organ-Specific γδ T Cell Compartments. Cell, 167 (1): 203-218.e17. [PMID:27641500]
2. Lebrero-Fernández C, Wenzel UA, Akeus P, Wang Y, Strid H, Simrén M, Gustavsson B, Börjesson LG, Cardell SL, Öhman L et al.. (2016) Altered expression of Butyrophilin (BTN) and BTN-like (BTNL) genes in intestinal inflammation and colon cancer. Immun Inflamm Dis, 4 (2): 191-200. [PMID:27957327]
3. Shibui A, Tsunoda T, Seki N, Suzuki Y, Sugano S, Sugane K. (1999) Cloning, expression analysis, and chromosomal localization of a novel butyrophilin-like receptor. J Hum Genet, 44 (4): 249-52. [PMID:10429365]
How to cite this page
Butyrophilin and butyrophilin-like proteins: butyrophilin like 3. Last modified on 07/08/2019. Accessed on 07/11/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=2944.
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