Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	407	1q23.1	MNDA	myeloid cell nuclear differentiation antigen
Rat	-	438	13q24	Mnda	myeloid cell nuclear differentiation antigen
Gene and Protein Information Comments
There are no mouse homologs of human MNDA.

Previous and Unofficial Names

PYHIN3

Database Links
Alphafold	P41218 (Hs)
Ensembl Gene	ENSG00000163563 (Hs), ENSRNOG00000003486 (Rn)
Entrez Gene	4332 (Hs), 304988 (Rn)
Human Protein Atlas	ENSG00000163563 (Hs)
KEGG Gene	hsa:4332 (Hs), rno:304988 (Rn)
OMIM	159553 (Hs)
Pharos	P41218 (Hs)
RefSeq Nucleotide	NM_002432 (Hs), NM_001012029 (Rn)
RefSeq Protein	NP_002423 (Hs), NP_001012029 (Rn)
UniProtKB	P41218 (Hs)
Wikipedia	MNDA (Hs)

Agonist Comments

The HIN (ligand binding) domain of MDNA binds double-stranded DNA with a Kd of 3.15 μM [2].

Immunopharmacology Comments

MNDA can be detected exclusively in nuclei of hematopoietic cells of the monocyte lineage. Expression is induced by interferon α [1]. The HIN domain of MNDA binds double-stranded DNA [2], and produces an innate resonse against pathogens. MNDA may be able to detect some viruses not recognized by AIM2.

Immuno Process Associations

Immuno Process:  Inflammation

Immuno Process:  B cell (activation)

Immuno Process:  Immune regulation

Immuno Process:  Cellular signalling

Immuno Process:  Cytokine production & signalling

General Comments
MNDA is a member of the ALR pattern recognition receptor family, a set of four related human genes classified by structural similarities as the Pyrin and HIN domain family (HGNC family 995).