Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	492	1q23.1	PYHIN1	pyrin and HIN domain family member 1
Gene and Protein Information Comments
Alternative transcription of the human gene gives rise to several protein isoforms: alpha 1 (presented here), alpha 2, beta a and beta 2. There are no mouse or rat homologs of human PYHIN1 with 1:1 orthology.

Previous and Unofficial Names

IFIX i [2]

Database Links
Alphafold	Q6K0P9 (Hs)
Ensembl Gene	ENSG00000163564 (Hs)
Entrez Gene	149628 (Hs)
Human Protein Atlas	ENSG00000163564 (Hs)
KEGG Gene	hsa:149628 (Hs)
OMIM	612677 (Hs)
Pharos	Q6K0P9 (Hs)
RefSeq Nucleotide	NM_152501 (Hs)
RefSeq Protein	NP_689714 (Hs)
UniProtKB	Q6K0P9 (Hs)
Wikipedia	PYHIN1 (Hs)

Immunopharmacology Comments

PYHIN1 participates in the innate immune response to microbial DNA [1], and contributes to the induction of the interferon response to viral pathogens.

General Comments
PYHIN1 is a member of the ALR pattern recognition receptor family, a set of four related human genes classified by structural similarities as the Pyrin and HIN domain family (HGNC family 995). In addition to acting as a sensor of viral DNA, PYHIN1 also interacts with factors involved in transcriptional regulation and chromatin modulation [1].