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MT2 receptor

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Target id: 288

Nomenclature: MT2 receptor

Family: Melatonin receptors

Contents:

Gene and Protein Information Click here for help
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 362 11q14.3 MTNR1B melatonin receptor 1B 54-55
Mouse 7 364 9 A2 Mtnr1b melatonin receptor 1B 32
Rat 7 364 8q12 Mtnr1b melatonin receptor 1B 3
Gene and Protein Information Comments
The ovine MT2 receptor has been shown to present 72% identity with the human receptor [14].
Previous and Unofficial Names Click here for help
mel1b receptor
Database Links Click here for help
Specialist databases
GPCRdb mtr1b_human (Hs), mtr1b_mouse (Mm)
Other databases
Alphafold P49286 (Hs), Q8CIQ6 (Mm), P49287 (Rn)
ChEMBL Target CHEMBL1946 (Hs), CHEMBL2566 (Rn)
DrugBank Target P49286 (Hs)
Ensembl Gene ENSG00000134640 (Hs), ENSMUSG00000050901 (Mm), ENSRNOG00000008972 (Rn)
Entrez Gene 4544 (Hs), 244701 (Mm), 192646 (Rn)
Human Protein Atlas ENSG00000134640 (Hs)
KEGG Gene hsa:4544 (Hs), mmu:244701 (Mm), rno:192646 (Rn)
OMIM 600804 (Hs)
Pharos P49286 (Hs)
RefSeq Nucleotide NM_005959 (Hs), NM_145712 (Mm), NM_001100641 (Rn)
RefSeq Protein NP_005950 (Hs), NP_663758 (Mm), NP_001094111 (Rn)
UniProtKB P49286 (Hs), Q8CIQ6 (Mm), P49287 (Rn)
Wikipedia MTNR1B (Hs)
Selected 3D Structures Click here for help
Image of receptor 3D structure from RCSB PDB
Description:  MT2 receptor crystalized in the inactive state in the presence of ramelteon.
PDB Id:  6ME9
Ligand:  ramelteon
Resolution:  3.3Å
Species:  Human
References:  33
Image of receptor 3D structure from RCSB PDB
Description:  MT2 receptor crystalized in the inactive state in the presence of 2-phenylmelatonin.
PDB Id:  6ME6
Resolution:  2.8Å
Species:  Human
References:  33
Associated Proteins Click here for help
Interacting Proteins
Name Effect References
MT1 receptor 5-6
GPR50 40
Natural/Endogenous Ligands Click here for help
melatonin

Download all structure-activity data for this target as a CSV file go icon to follow link

Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
[125I]S70254 Small molecule or natural product Ligand is labelled Ligand is radioactive Hs Partial agonist 9.6 – 11.0 pKd 38-39
⤷ pKd 11.0 (Kd 1.1x10-11 M) [38-39]
pKd 9.6 [39]
[125I]SD6 Small molecule or natural product Click here for species-specific activity table Ligand is labelled Ligand is radioactive Hs Full agonist 10.2 – 10.2 pKd 38-39
⤷ pKd 10.2 (Kd 6.6x10-11 M) [39]
pKd 10.2 (Kd 6.6x10-11 M) [38-39]
[125I]DIV880 Small molecule or natural product Ligand is labelled Ligand is radioactive Hs Partial agonist 9.7 – 10.3 pKd 38-39
⤷ pKd 10.3 (Kd 5.5x10-11 M) [38-39]
pKd 9.7 (Kd 2.24x10-10 M) [39]
2-[125I]melatonin Small molecule or natural product Click here for species-specific activity table Ligand is labelled Ligand is radioactive Hs Full agonist 9.7 – 10.0 pKd 4,23
⤷ pKd 9.7 – 10.0 (Kd 1.86x10-10 – 1.07x10-10 M) [4,23]
[3H]melatonin Small molecule or natural product Click here for species-specific activity table Ligand is labelled Ligand is radioactive Ligand has a PDB structure Hs Full agonist 9.0 – 9.6 pKd 11
⤷ pKd 9.0 – 9.6 (Kd 9.12x10-10 – 2.8x10-10 M) [11]
UCM1014 Small molecule or natural product Primary target of this compound Hs Full agonist 12.0 pKi 65
⤷ pKi 12.0 (Ki 1x10-12 M) [65]
isoamyl-agomelatine Small molecule or natural product Hs Partial agonist 11.0 pKi 27
⤷ pKi 11.0 [27]
CIFEA Small molecule or natural product Hs Full agonist 10.9 pKi 35
⤷ pKi 10.9 [35]
LY 156735 Small molecule or natural product Click here for species-specific activity table Hs Full agonist 10.4 pKi 46
⤷ pKi 10.4 [46]
IIK7 Small molecule or natural product Click here for species-specific activity table Hs Full agonist 10.3 pKi 28,67
⤷ pKi 10.3 (Ki 5x10-11 M) [28,67]
IIK7 Small molecule or natural product Mm Full agonist 10.3 pKi 7
⤷ pKi 10.3 (Ki 5.2x10-11 M) [7]
agomelatine Small molecule or natural product Approved drug Primary target of this compound Click here for species-specific activity table Ligand has a PDB structure Hs Full agonist 9.9 – 10.5 pKi 4,9
⤷ pKi 9.9 – 10.5 [4,9]
tasimelteon Small molecule or natural product Approved drug Primary target of this compound Click here for species-specific activity table Hs Full agonist 10.2 pKi 52,71
⤷ pKi 10.2 (Ki 6.92x10-11 M) [52,71]
UCM 765 Small molecule or natural product Hs Full agonist 10.2 pKi 56
⤷ pKi 10.2 [56]
2-iodo-melatonin Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Full agonist 9.7 – 10.3 pKi 4,9,20,23
⤷ pKi 9.7 – 10.3 [4,9,20,23]
ramelteon Small molecule or natural product Approved drug Primary target of this compound Click here for species-specific activity table Ligand has a PDB structure Hs Full agonist 10.0 pKi 34,53
⤷ pKi 10.0 [34,53]
GR 196429 Small molecule or natural product Click here for species-specific activity table Hs Full agonist 9.7 – 9.8 pKi 9,11
⤷ pKi 9.7 – 9.8 [9,11]
melatonin Small molecule or natural product Approved drug Primary target of this compound Click here for species-specific activity table Ligand is endogenous in the given species Ligand has a PDB structure Immunopharmacology Ligand Hs Full agonist 9.4 – 9.8 pKi 4,20,23
⤷ pKi 9.4 – 9.8 [4,20,23]
6-Cl-MLT Small molecule or natural product Click here for species-specific activity table Hs Full agonist 9.4 – 9.8 pKi 4,9,20,23
⤷ pKi 9.4 – 9.8 [4,9,20,23]
S24014 Small molecule or natural product Click here for species-specific activity table Hs Partial agonist 9.6 pKi 4
⤷ pKi 9.6 [4]
5-methoxy-luzindole Small molecule or natural product Hs Partial agonist 9.6 pKi 23
⤷ pKi 9.6 (Ki 2.5x10-10 M) [23]
BOMPPA Small molecule or natural product Hs Full agonist 9.5 pKi 30
⤷ pKi 9.5 [30]
S24773 Small molecule or natural product Click here for species-specific activity table Hs Partial agonist 9.3 – 9.6 pKi 4
⤷ pKi 9.3 – 9.6 [4]
EFPPEA Small molecule or natural product Click here for species-specific activity table Hs Full agonist 9.4 pKi 36
⤷ pKi 9.4 [36]
UCM 793 Small molecule or natural product Click here for species-specific activity table Hs Full agonist 9.2 pKi 56
⤷ pKi 9.2 [56]
GR 128107 Small molecule or natural product Click here for species-specific activity table Hs Partial agonist 8.6 – 9.1 pKi 23,70
⤷ pKi 8.6 – 9.1 [23,70]
UCM1341 Small molecule or natural product Click here for species-specific activity table Hs Agonist 8.8 pKi 64
⤷ pKi 8.8 (Ki 1.7x10-9 M) [64]
6-hydroxymelatonin Small molecule or natural product Click here for species-specific activity table Hs Full agonist 8.3 – 8.8 pKi 11,20,23
⤷ pKi 8.3 – 8.8 [11,20,23]
S22153 Small molecule or natural product Click here for species-specific activity table Hs Partial agonist 8.1 – 8.2 pKi 4
⤷ pKi 8.1 – 8.2 [4]
S26284 Small molecule or natural product Click here for species-specific activity table Hs Partial agonist 6.8 – 7.2 pKi 4
⤷ pKi 6.8 – 7.2 [4]
ICOA-13 Small molecule or natural product Click here for species-specific activity table Ligand is labelled Hs Full agonist 5.5 pKi 29
⤷ pKi 5.5 (Ki 3.313x10-6 M) [29]
Description: For ERK1/2 activation.
UCSF4226 Small molecule or natural product Click here for species-specific activity table Hs Agonist 8.1 pEC50 66
⤷ pEC50 8.1 (EC50 7.08x10-9 M) [66]
UCSF3384 Small molecule or natural product Click here for species-specific activity table Hs Inverse agonist 6.2 pEC50 66
⤷ pEC50 6.2 (EC50 6.31x10-7 M) [66]
UCSF7447 Small molecule or natural product Click here for species-specific activity table Hs Inverse agonist 6.0 pEC50 66
⤷ pEC50 6.0 (EC50 1.024x10-6 M) [66]
View species-specific agonist tables
Agonist Comments
The partial agonists DIV880 and S70254 are the first reported selective ligands for the MT2 receptor subtype [39]. The partial antagonist GR 128107 has also been classed as an antagonist.
ICOA-13 is a full agonist for ERK1/2 activation at the MT2 receptor, but is a partial agonist for inhibition of cAMP production and β-arrestin2 recruitment [29].
Antagonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
(hydroxymethylphenyl)agomelatine Small molecule or natural product Hs Antagonist 9.4 pKi 51
⤷ pKi 9.4 (Ki 3.6x10-10 M) [51]
K185 Small molecule or natural product Click here for species-specific activity table Hs Antagonist 9.3 pKi 28,67
⤷ pKi 9.3 (Ki 5.1x10-10 M) [28,67]
4P-PDOT Small molecule or natural product Click here for species-specific activity table Hs Antagonist 8.8 – 9.4 pKi 4,23,25
⤷ pKi 8.8 – 9.4 (Ki 1.58x10-9 – 3.9x10-10 M) [4,23,25]
UCM 549 Small molecule or natural product Click here for species-specific activity table Hs Antagonist 8.9 – 9.2 pKi 42,63
⤷ pKi 8.9 – 9.2 [42,63]
2-(indolin-1yl)-melatonin Small molecule or natural product Hs Antagonist 8.9 pKi 73
⤷ pKi 8.9 [73]
UCM 454 Small molecule or natural product Hs Antagonist 8.1 pKi 57
⤷ pKi 8.1 [57]
DH97 Small molecule or natural product Hs Antagonist 8.0 pKi 69
⤷ pKi 8.0 (Ki 1x10-8 M) [69]
UCM 724 Small molecule or natural product Click here for species-specific activity table Hs Antagonist 8.0 pKi 42
⤷ pKi 8.0 [42]
luzindole Small molecule or natural product Click here for species-specific activity table Hs Antagonist 7.6 – 8.1 pKi 4,11,21,23,25
⤷ pKi 7.6 – 8.1 [4,11,21,23,25]
S20928 Small molecule or natural product Click here for species-specific activity table Hs Antagonist 7.1 – 7.2 pKi 4
⤷ pKi 7.1 – 7.2 [4]
5-HEAT Small molecule or natural product Click here for species-specific activity table Hs Antagonist 7.1 pKi 49
⤷ pKi 7.1 [49]
S26131 Small molecule or natural product Click here for species-specific activity table Hs Antagonist 6.8 – 7.0 pKi 4
⤷ pKi 6.8 – 7.0 [4]
Primary Transduction Mechanisms Click here for help
Transducer Effector/Response
Gi/Go family Adenylyl cyclase inhibition
Phospholipase C stimulation
References:  24,31,43,45,54
Secondary Transduction Mechanisms Click here for help
Transducer Effector/Response
Other - See Comments
Comments:  Guanylate cyclase inhibition.
References:  50
Tissue Distribution Click here for help
Brown and white adipose tissue, PAZ6 adipocytes.
Species:  Human
Technique:  RT-PCR.
References:  12
Granulosa cells.
Species:  Human
Technique:  RT-PCR.
References:  48,62
Uveal melanocytes and melanoma cells.
Species:  Human
Technique:  RT-PCR.
References:  58
Hippocampus.
Species:  Human
Technique:  immunocytochemistry.
References:  60
Placental tissues and choriocarcinoma cell lines.
Species:  Human
Technique:  RT-PCR, Western blotting and confocal microscopy.
References:  37
Retina.
Species:  Human
Technique:  RT-PCR.
References:  54
Fetal kidney.
Species:  Human
Technique:  RT-PCR.
References:  19
Cerebellum.
Species:  Human
Technique:  in situ hybridisation.
References:  1
Brain: striatum.
Species:  Mouse
Technique:  Western blot and immunoprecipitation.
References:  8
Brain, lung.
Species:  Mouse
Technique:  RT-PCR.
References:  47
Retina.
Species:  Mouse
Technique:  In situ hybridisation
References:  15
Hypothalamus, retina, small intestine > liver, heart SA node.
Species:  Rat
Technique:  RT-PCR.
References:  59
Expression Datasets Click here for help

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Functional Assays Click here for help
Measurement of cAMP levels in CHO cells transfected with the human MT2 receptor.
Species:  Human
Tissue:  CHO cells.
Response measured:  Inhibition of cAMP accumulation.
References:  11,34
Measurement of cAMP levels in NIH 3T3 cells transfected with the human MT2 receptor.
Species:  Human
Tissue:  NIH 3T3 cells.
Response measured:  Inhibition of cAMP accumulation.
References:  28
Measurement of [35S]GTPγS binding in CHO cells transfected with the human MT2 receptor.
Species:  Human
Tissue:  CHO cells.
Response measured:  [35S]GTPγS binding.
References:  4
Measurement of [35S]GTPγS binding in NIH 3T3 cells transfected with the human MT2 receptor.
Species:  Human
Tissue:  NIH 3T3 cells.
Response measured:  [35S]GTPγS binding.
References:  49
Measurement of melatonin-mediated vasodilation in rat caudal arteries.
Species:  Rat
Tissue:  Caudal artery.
Response measured:  Vasodilation.
References:  16,44
Measurement of phase advance circadian rhythm neuronal firing in the mouse suprachiasmatic nucleus.
Species:  Mouse
Tissue:  Suprachiasmatic nucleus slice.
Response measured:  Phase shift of peak neuronal activity.
References:  22,41,53
Physiological Functions Click here for help
Increase in splenic lymphocyte proliferation.
Species:  Mouse
Tissue:  Splenocytes.
References:  17-18
Inhibition of proliferation.
Species:  Human
Tissue:  Choriocarcinoma JAr Cells.
References:  61
Physiological Consequences of Altering Gene Expression Click here for help
MT2 receptor knockout mice do not exhibit melatonin-mediated hippocampal LTP, as seen in wild-type mice.
Species:  Mouse
Tissue: 
Technique:  Transgenesis.
References:  72
MT2 receptor knockout mice do not exhibit luzindole-mediated antidepressant-like actions, as seen in wild-type mice.
Species:  Mouse
Tissue: 
Technique:  Transgenesis.
References:  68
MT2 receptor knockout mice are less sensitive to amphetamine than wild type mice and show increased dopamine uptake in striatal synaptosomes.
Species:  Mouse
Tissue: 
Technique:  Transgenesis.
References:  8
Phenotypes, Alleles and Disease Models Click here for help Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Mtnr1btm1Drw Mtnr1btm1Drw/Mtnr1btm1Drw
C3.129S4-Mtnr1b		 MGI:2181726  MP:0002169 no abnormal phenotype detected PMID: 12529409 
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Diabetes mellitus, noninsulin-dependent; NIDDM
Synonyms: Diabetes mellitus, Type II; T2D [OMIM: 125853]
Maturity onset diabetes
Type 2 diabetes mellitus [Disease Ontology: DOID:9352]
Disease Ontology: DOID:9352
OMIM: 125853
Role:  Mutation in the gene MTNR1B are associated with susceptibility to type II diabetes
Click column headers to sort
Type Species Amino acid change Nucleotide change Description Reference
Missense Human A42P Very rare variant identified in type 2 diabetes patients, associated with type 2 diabetes risk, no melatonin binding and signaling 10
Missense Human L60R Very rare variant identified in control population and type 2 diabetes patients, associated with type 2 diabetes risk, no melatonin binding and signaling 2,10
Missense Human P95L Very rare variant identified in type 2 diabetes patients, associated with type 2 diabetes risk, no melatonin binding and signaling 10
Missense Human Y308S Very rare variant identified in type 2 diabetes patients, associated with type 2 diabetes risk, no melatonin binding and signaling 10
Biologically Significant Variants Click here for help
Type:  Missense mutation
Species:  Human
Description:  Very rare variant identified in type 2 diabetes patients, associated with type 2 diabetes risk, impaired Gi protein activation
Amino acid change:  R330W
Nucleotide accession:  NM_005959
Protein accession:  NP_005950
References:  10
Type:  Missense mutation
Species:  Human
Description:  Very rare variant identified in type 2 diabetes patients, without obvious functional defect
Amino acid change:  A342V
Nucleotide accession:  NM_005959
Protein accession:  NP_005950
References:  10
Type:  Missense mutation
Species:  Human
Description:  Very rare variant identified in control population without obvious functional defect
Amino acid change:  A359E
Nucleotide accession:  NM_005959
Protein accession:  NP_005950
References:  10
Type:  Missense mutation
Species:  Human
Description:  Very rare variant identified in type 2 diabetes patients and control population, associated with type 2 diabetes risk, impaired Gi protein activation
Amino acid change:  I353T
Nucleotide accession:  NM_005959
Protein accession:  NP_005950
References:  10
Type:  Missense mutation
Species:  Human
Description:  Rare variant, not associated with type 2 diabetes risk, no Gi and ERK1/2 activation
Amino acid change:  R138C
Nucleotide accession:  NM_005959
Protein accession:  NP_005950
References:  2,10,13
Type:  Missense mutation
Species:  Human
Description:  Common variant, not associated with type 2 diabetes risk but associated with prevalence of obesity and increased BMI shown in one study but not in another
Amino acid change:  G24E
Nucleotide accession:  NM_005959
Protein accession:  NP_005950
References:  2,10,13,26
Type:  Missense mutation
Species:  Human
Description:  Very rare variant identified in control population without obvious functional defect
Amino acid change:  G21S
Nucleotide accession:  NM_005959
Protein accession:  NP_005950
References:  10
Type:  Missense mutation
Species:  Human
Description:  Very rare variant identified in control population without obvious functional defect
Amino acid change:  R330Q
Nucleotide accession:  NM_005959
Protein accession:  NP_005950
References:  13
Type:  Missense mutation
Species:  Human
Description:  Very rare variant identified in control population without obvious functional defect
Amino acid change:  A234T
Nucleotide accession:  NM_005959
Protein accession:  NP_005950
References:  10
Type:  Missense mutation
Species:  Human
Description:  Very rare variant identified in control population without obvious functional defect
Amino acid change:  E237K
Nucleotide accession:  NM_005959
Protein accession:  NP_005950
References:  10
Type:  Missense mutation
Species:  Human
Description:  Very rare variant identified in control population without obvious functional defect
Amino acid change:  A13V
Nucleotide accession:  NM_005959
Protein accession:  NP_005950
References:  10
Type:  Missense mutation
Species:  Human
Description:  Very rare variant identified in control population without obvious functional defect
Amino acid change:  A25T
Nucleotide accession:  NM_005959
Protein accession:  NP_005950
References:  10
Type:  Missense mutation
Species:  Human
Description:  Very rare variant identified in control population without obvious functional defect
Amino acid change:  A8S
Nucleotide accession:  NM_005959
Protein accession:  NP_005950
References:  10
Type:  Missense mutation
Species:  Human
Description:  Very rare variant identified in control population without obvious functional defect
Amino acid change:  R316H
Nucleotide accession:  NM_005959
Protein accession:  NP_005950
References:  10
Type:  Missense mutation
Species:  Human
Description:  Very rare variant identified in type 2 diabetes patients, without obvious functional defect
Amino acid change:  S238G
Nucleotide accession:  NM_005959
Protein accession:  NP_005950
References:  10
Type:  Missense mutation
Species:  Human
Description:  Common variant, not associated with type 2 diabetes risk
Amino acid change:  K243R
Nucleotide accession:  NM_005959
Protein accession:  NP_005950
References:  2,10,13
Type:  Missense mutation
Species:  Human
Description:  Very rare variant identified in type 2 diabetes patients, without obvious functional defect
Amino acid change:  D246N
Nucleotide accession:  NM_005959
Protein accession:  NP_005950
References:  10
Type:  Missense mutation
Species:  Human
Description:  Very rare variant identified in type 2 diabetes patients, without obvious functional defect
Amino acid change:  P36S
Nucleotide accession:  NM_005959
Protein accession:  NP_005950
References:  10
Type:  Missense mutation
Species:  Human
Description:  Very rare variant identified in type 2 diabetes patients with impaired ERK1/2 activation
Amino acid change:  F250V
Nucleotide accession:  NM_005959
Protein accession:  NP_005950
References:  10
Type:  Missense mutation
Species:  Human
Description:  Very rare variant identified in control population, associated with type 2 diabetes risk, impaired Gi protein activation
Amino acid change:  R138H
Nucleotide accession:  NM_005959
Protein accession:  NP_005950
References:  10
Type:  Missense mutation
Species:  Human
Description:  Very rare variant identified in type 2 diabetes patients, associated with type 2 diabetes risk, impaired Gi protein activation
Amino acid change:  W22L
Nucleotide accession:  NM_005959
Protein accession:  NP_005950
References:  10
Type:  Missense mutation
Species:  Human
Description:  Rare variant, not associated with type 2 diabetes risk
Amino acid change:  R231H
Nucleotide accession:  NM_005959
Protein accession:  NP_005950
References:  2,10,13
Type:  Missense mutation
Species:  Human
Description:  Very rare variant identified in control population without obvious functional defect
Amino acid change:  M146V
Nucleotide accession:  NM_005959
Protein accession:  NP_005950
References:  10
Type:  Missense mutation
Species:  Human
Description:  Very rare variant identified in control population without obvious functional defect
Amino acid change:  M120V
Nucleotide accession:  NM_005959
Protein accession:  NP_005950
References:  10,13
Type:  Missense mutation
Species:  Human
Description:  Very rare variant identified in control population, associated with type 2 diabetes risk, impaired Gi protein activation
Amino acid change:  L166I
Nucleotide accession:  NM_005959
Protein accession:  NP_005950
References:  10
Type:  Missense mutation
Species:  Human
Description:  Very rare variant identified in population with impaired fasting glucose and control population without obvious functional defect
Amino acid change:  M120I
Nucleotide accession:  NM_005959
Protein accession:  NP_005950
References:  10
Type:  Missense mutation
Species:  Human
Description:  Very rare variant identified in population with impaired fasting glucose and control population without obvious functional defect
Amino acid change:  S123R
Nucleotide accession:  NM_005959
Protein accession:  NP_005950
References:  10
Type:  Missense mutation
Species:  Human
Description:  Very rare variant identified in type 2 diabetes patients, associated with type 2 diabetes risk, impaired Gi protein activation
Amino acid change:  R222H
Nucleotide accession:  NM_005959
Protein accession:  NP_005950
References:  10
Type:  Missense mutation
Species:  Human
Description:  Very rare variant identified in type 2 diabetes patients, without obvious functional defect
Amino acid change:  I223T
Nucleotide accession:  NM_005959
Protein accession:  NP_005950
References:  10
Type:  Missense mutation
Species:  Human
Description:  Very rare variant identified in type 2 diabetes patients, without obvious functional defect
Amino acid change:  Y141F
Nucleotide accession:  NM_005959
Protein accession:  NP_005950
References:  10
Type:  Missense mutation
Species:  Human
Description:  Very rare variant identified in type 2 diabetes patients, without obvious functional defect
Amino acid change:  T201M
Nucleotide accession:  NM_005959
Protein accession:  NP_005950
References:  10
Type:  Missense mutation
Species:  Human
Description:  Very rare variant identified in type 2 diabetes patients, associated with type 2 diabetes risk, impaired Gi protein activation
Amino acid change:  A52T
Nucleotide accession:  NM_005959
Protein accession:  NP_005950
References:  10
Type:  Missense mutation
Species:  Human
Description:  Very rare variant identified in control population and type 2 diabetes patients without obvious functional defect
Amino acid change:  R154H
Nucleotide accession:  NM_005959
Protein accession:  NP_005950
References:  10
Type:  Missense mutation
Species:  Human
Description:  Very rare variant identified in control population, associated with type 2 diabetes risk, impaired Gi protein activation
Amino acid change:  R138L
Nucleotide accession:  NM_005959
Protein accession:  NP_005950
References:  10
Type:  Missense mutation
Species:  Human
Description:  Very rare variant identified in several populations including type 2 diabetes and ADSD without obvious functional defect in one study and impaired ERK1/2 activation in another
Amino acid change:  V124I
Nucleotide accession:  NM_005959
Protein accession:  NP_005950
References:  2,10,13
Type:  Missense mutation
Species:  Human
Description:  Very rare variant identified in control population without obvious functional defect
Amino acid change:  G109A
Nucleotide accession:  NM_005959
Protein accession:  NP_005950
References:  10
Type:  Missense mutation
Species:  Human
Description:  Very rare variant identified in control population without obvious functional defect
Amino acid change:  L66F
Nucleotide accession:  NM_005959
Protein accession:  NP_005950
References:  26
Type:  Missense mutation
Species:  Human
Description:  Very rare variant identified in control population and type 2 diabetes patients, associated with type 2 diabetes risk, impaired Gi protein activation
Amino acid change:  A74T
Nucleotide accession:  NM_005959
Protein accession:  NP_005950
References:  10

References

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