Synonyms: compound 29 [PMID: 30126274] | UCM-1341
Compound class:
Synthetic organic
Comment: UCM1341 is a bivalent compound that combines the pharmacophore elements of a melatonin receptor agonist and a fatty acid amide hydrolase (FAAH) inhibitor (derived from URB597) [2]. It was originally reported for potential benefits for the treatment of glaucoma (inducing an ocular hypotensive effect in vivo) [2]. More recently data has been published which supports activity that is neuroprotective and which promotes resolution of inflammation (in a rodent hippocampal explant model of neuroinflammatory damage) [1].
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Classification | |
Compound class | Synthetic organic |
Synonyms |
compound 29 [PMID: 30126274] | UCM-1341 |
Database Links | |
Specialist databases | |
GPCRdb Ligand | UCM1341 |
Other databases | |
BindingDB Ligand | 50458979 |
ChEMBL Ligand | CHEMBL4210086 |
GtoPdb PubChem SID | 479821115 |
PubChem CID | 145966622 |
Search Google for chemical match using the InChIKey | SVUSBZIJILRPDJ-UHFFFAOYSA-N |
Search Google for chemicals with the same backbone | SVUSBZIJILRPDJ |
UniChem Compound Search for chemical match using the InChIKey | SVUSBZIJILRPDJ-UHFFFAOYSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | SVUSBZIJILRPDJ-UHFFFAOYSA-N |