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Interleukin-11 receptor

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Target id: 2311

Nomenclature: Interleukin-11 receptor

Family: IL-6 receptor family

Quaternary Structure: Subunits
Interleukin-11 receptor, α subunit (Ligand-binding subunit)
Interleukin-6 receptor, β subunit (Other subunit)
Natural/Endogenous Ligands Click here for help
IL-11 {Sp: Human}

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Agonists
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Ligand Sp. Action Value Parameter Reference
IL-11 {Sp: Human} Peptide Ligand is endogenous in the given species Immunopharmacology Ligand Hs Agonist - -
oprelvekin Peptide Approved drug Primary target of this compound Immunopharmacology Ligand Hs Full agonist - - 1,4
[1,4]
Agonist Comments
Recombinant human IL-11 promotes cellular proliferation of Ba/F3 cells exogenously expressing IL-11 receptors, with an EC50 value of 2.5ng/mL [3].
Immunopharmacology Comments
The interleukin-11 receptor is a heterodimer of a ligand binding α subunit (IL11RA) and a signal transducing interleukin-6 receptor, β subunit (IL6ST) [2]. It is a type I cytokine receptor for stromal cell-derived IL-11, a cytokine with multiple biologic activities on lymphohematopoietic and bone cells.

References

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1. Berl T, Schwertschlag U. (2000) Preclinical pharmacologic basis for clinical use of rhIL-11 as an effective platelet-support agent. Oncology (Williston Park, NY), 14 (9 Suppl 8): 12-20. [PMID:11033834]

2. Chérel M, Sorel M, Lebeau B, Dubois S, Moreau JF, Bataille R, Minvielle S, Jacques Y. (1995) Molecular cloning of two isoforms of a receptor for the human hematopoietic cytokine interleukin-11. Blood, 86 (7): 2534-40. [PMID:7670098]

3. Jung Y, Ahn H, Kim DS, Hwang YR, Ho SH, Kim JM, Kim S, Ma S, Kim S. (2011) Improvement of biological and pharmacokinetic features of human interleukin-11 by site-directed mutagenesis. Biochem Biophys Res Commun, 405 (3): 399-404. [PMID:21238428]

4. Wilde MI, Faulds D. (1998) Oprelvekin: a review of its pharmacology and therapeutic potential in chemotherapy-induced thrombocytopenia. BioDrugs, 10 (2): 159-71. [PMID:18020592]

How to cite this page

IL-6 receptor family: Interleukin-11 receptor. Last modified on 07/04/2017. Accessed on 26/01/2022. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=2311.