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Interleukin-6 receptor, β subunit

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Target id: 2317

Nomenclature: Interleukin-6 receptor, β subunit

Abbreviated Name: IL6ST

Systematic Nomenclature: interleukin 6 signal transducer

Family: IL-6 receptor family

Contents:

Quaternary Structure: Complexes
Interleukin-6 receptor
Interleukin-11 receptor
Ciliary neutrophic factor receptor
Leukemia inhibitory factor receptor
Oncostatin-M receptor
Interleukin-27 receptor
Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 918 5q11.2 IL6ST interleukin 6 cytokine family signal transducer
Mouse 1 917 13 63.73 cM Il6st interleukin 6 signal transducer
Rat 1 918 2q14-q16 Il6st interleukin 6 cytokine family signal transducer
Previous and Unofficial Names Click here for help
CD130 | gp130 | interleukin-6 receptor subunit beta | membrane glycoprotein 130 | oncostatin-M receptor subunit alpha | interleukin 6 signal transducer (gp130, oncostatin M receptor) | interleukin 6 signal transducer
Database Links Click here for help
Alphafold P40189 (Hs), Q00560 (Mm), P40190 (Rn)
CATH/Gene3D 2.60.40.10
ChEMBL Target CHEMBL3124734 (Hs)
Ensembl Gene ENSG00000134352 (Hs), ENSMUSG00000021756 (Mm), ENSRNOG00000013963 (Rn)
Human Protein Atlas ENSG00000134352 (Hs)
OMIM 600694 (Hs)
Pharos P40189 (Hs)
UniProtKB P40189 (Hs), Q00560 (Mm), P40190 (Rn)
Wikipedia IL6ST (Hs)
Selected 3D Structures Click here for help
Image of receptor 3D structure from RCSB PDB
Description:  Cytokine-binding region of gp130
PDB Id:  1BQU
Resolution:  2.0Å
Species:  Human
References:  1
Immunopharmacology Comments
This is the common signal transducing subunit shared by members of the IL-6 family of cytokine receptors [2].
IL-6/IL-6R regulated signalling pathways represent a druggable target for the therapy of chronic inflammatory and autoimmune diseases, and cancer [3]. IL6ST (gp130) is being investigated as therapeutic target for the treatment of autoimmune diseases [3-4]. For example i-Mab Biopharma have a gp130 targeting Fc fusion protein (olamkicept; TJ301) in early stage clinical trial in patients with active ulcerative colitis (Ph2 NCT03235752).
Immuno Process Associations
Immuno Process:  Inflammation
Immuno Process:  T cell (activation)
Immuno Process:  B cell (activation)
Immuno Process:  Immune regulation
Immuno Process:  Cytokine production & signalling
Immuno Process:  Chemotaxis & migration
Immuno Process:  Cellular signalling

References

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1. Bravo J, Staunton D, Heath JK, Jones EY. (1998) Crystal structure of a cytokine-binding region of gp130. EMBO J, 17 (6): 1665-74. [PMID:9501088]

2. Rose-John S. (2018) Interleukin-6 Family Cytokines. Cold Spring Harb Perspect Biol, 10 (2). [PMID:28620096]

3. Rose-John S, Waetzig GH, Scheller J, Grötzinger J, Seegert D. (2007) The IL-6/sIL-6R complex as a novel target for therapeutic approaches. Expert Opin Ther Targets, 11 (5): 613-24. [PMID:17465721]

4. Shaw S, Bourne T, Meier C, Carrington B, Gelinas R, Henry A, Popplewell A, Adams R, Baker T, Rapecki S et al.. (2014) Discovery and characterization of olokizumab: a humanized antibody targeting interleukin-6 and neutralizing gp130-signaling. MAbs, 6 (3): 774-82. [PMID:24670876]

How to cite this page

IL-6 receptor family: Interleukin-6 receptor, β subunit. Last modified on 15/04/2019. Accessed on 11/12/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=2317.