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NIMA related kinase 5

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Target id: 2120

Nomenclature: NIMA related kinase 5

Abbreviated Name: NEK5

Family: NIMA (never in mitosis gene a)- related kinase (NEK) family

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 708 13q14.3 NEK5 NIMA related kinase 5
Mouse - 627 8 A2 Nek5 NIMA (never in mitosis gene a)-related expressed kinase 5
Rat - - 16q12.5 Nek5 NIMA-related kinase 5
Previous and Unofficial Names Click here for help
NIMA-related kinase 5
Database Links Click here for help
Alphafold Q6P3R8 (Hs), Q7TSC3 (Mm)
BRENDA 2.7.11.1
ChEMBL Target CHEMBL5044 (Hs)
Ensembl Gene ENSG00000197168 (Hs), ENSMUSG00000037738 (Mm), ENSRNOG00000048769 (Rn)
Entrez Gene 341676 (Hs), 330721 (Mm), 685440 (Rn)
Human Protein Atlas ENSG00000197168 (Hs)
KEGG Enzyme 2.7.11.1
KEGG Gene hsa:341676 (Hs), mmu:330721 (Mm), rno:685440 (Rn)
Pharos Q6P3R8 (Hs)
RefSeq Nucleotide NM_199289 (Hs), NM_177898 (Mm)
RefSeq Protein NP_954983 (Hs), NP_808566 (Mm)
UniProtKB Q6P3R8 (Hs), Q7TSC3 (Mm)
Wikipedia NEK5 (Hs)
Enzyme Reaction Click here for help
EC Number: 2.7.11.1
DiscoveRx KINOMEscan® screen Click here for help
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform.
http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan
Reference: 1-2
Key to terms and symbols Click column headers to sort
Target used in screen: NEK5
Ligand Sp. Type Action Value Parameter
tamatinib Small molecule or natural product Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition 7.9 pKd
fedratinib Small molecule or natural product Approved drug Ligand has a PDB structure Hs Inhibitor Inhibition 6.2 pKd
staurosporine Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 6.1 pKd
PD-173955 Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 6.1 pKd
GSK-461364A Small molecule or natural product Hs Inhibitor Inhibition 6.0 pKd
AST-487 Small molecule or natural product Hs Inhibitor Inhibition 6.0 pKd
dovitinib Small molecule or natural product Hs Inhibitor Inhibition 5.6 pKd
KW-2449 Small molecule or natural product Hs Inhibitor Inhibition 5.6 pKd
SB203580 Small molecule or natural product Immunopharmacology Ligand Hs Inhibitor Inhibition <5.5 pKd
ruboxistaurin Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition <5.5 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »

References

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1. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol, 29 (11): 1046-51. [PMID:22037378]

2. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem Biol, 17 (11): 1241-9. [PMID:21095574]

How to cite this page

NIMA (never in mitosis gene a)- related kinase (NEK) family: NIMA related kinase 5. Last modified on 29/01/2016. Accessed on 19/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=2120.