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hormonally up-regulated Neu-associated kinase

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Target id: 2037

Nomenclature: hormonally up-regulated Neu-associated kinase

Abbreviated Name: HUNK

Family: HUNK subfamily

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 714 21q22.11 HUNK hormonally up-regulated Neu-associated kinase
Mouse - 714 16 51.71 cM Hunk hormonally upregulated Neu-associated kinase
Rat - 714 11 q11 Hunk hormonally upregulated Neu-associated kinase
Previous and Unofficial Names Click here for help
B19 | Bstk1 | MAK5 | Mak-v
Database Links Click here for help
Alphafold P57058 (Hs), O88866 (Mm)
BRENDA 2.7.11.1
ChEMBL Target CHEMBL1795165 (Hs)
Ensembl Gene ENSG00000142149 (Hs), ENSMUSG00000053414 (Mm), ENSRNOG00000002092 (Rn)
Entrez Gene 30811 (Hs), 26559 (Mm), 288275 (Rn)
Human Protein Atlas ENSG00000142149 (Hs)
KEGG Enzyme 2.7.11.1
KEGG Gene hsa:30811 (Hs), mmu:26559 (Mm), rno:288275 (Rn)
OMIM 606532 (Hs)
Pharos P57058 (Hs)
RefSeq Nucleotide NM_014586 (Hs), NM_015755 (Mm), NM_001191662 (Rn)
RefSeq Protein NP_055401 (Hs), NP_056570 (Mm), NP_001178591 (Rn)
UniProtKB P57058 (Hs), O88866 (Mm)
Wikipedia HUNK (Hs)
Enzyme Reaction Click here for help
EC Number: 2.7.11.1

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
HSL119 Small molecule or natural product Hs Inhibition - - 2
⤷ [2]
DiscoveRx KINOMEscan® screen Click here for help
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform.
http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan
Reference: 1,3
Key to terms and symbols Click column headers to sort
Target used in screen: HUNK
Ligand Sp. Type Action Value Parameter
SU-14813 Small molecule or natural product Hs Inhibitor Inhibition 8.4 pKd
midostaurin Small molecule or natural product Approved drug Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition 6.6 pKd
NVP-TAE684 Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 6.5 pKd
dovitinib Small molecule or natural product Hs Inhibitor Inhibition 6.4 pKd
KW-2449 Small molecule or natural product Hs Inhibitor Inhibition 6.3 pKd
sunitinib Small molecule or natural product Approved drug Ligand has a PDB structure Hs Inhibitor Inhibition 6.3 pKd
lestaurtinib Small molecule or natural product Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition 6.2 pKd
staurosporine Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 6.2 pKd
PHA-665752 Small molecule or natural product Hs Inhibitor Inhibition 5.8 pKd
axitinib Small molecule or natural product Approved drug Ligand has a PDB structure Hs Inhibitor Inhibition 5.8 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »

References

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1. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol, 29 (11): 1046-51. [PMID:22037378]

2. Dilday T, Abt M, Ramos-Solís N, Dayal N, Larocque E, Oblak AL, Sintim HO, Yeh ES. (2024) Identification and characterization of a potent and selective HUNK inhibitor for treatment of HER2+ breast cancer. Cell Chem Biol, [Epub ahead of print]. [PMID:38307028]

3. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem Biol, 17 (11): 1241-9. [PMID:21095574]

How to cite this page

HUNK subfamily: hormonally up-regulated Neu-associated kinase. Last modified on 05/02/2024. Accessed on 25/01/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=2037.