Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	1	283	1p36.32	TNFRSF14	TNF receptor superfamily member 14
Mouse	-	-		Tnfrsf14	tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)
Rat	-	-		Tnfrsf14	TNF receptor superfamily member 14

Previous and Unofficial Names

ATAR | Herpesvirus entry mediator A | HVEA | HVEM | TR2 | tumor necrosis factor receptor superfamily, member 14 | CD270 | LIGHTR | tumor necrosis factor receptor superfamily | tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)

Database Links
Alphafold	Q92956 (Hs)
Ensembl Gene	ENSG00000157873 (Hs), ENSMUSG00000042333 (Mm), ENSRNOG00000013820 (Rn)
Entrez Gene	8764 (Hs), 230979 (Mm), 366518 (Rn)
Human Protein Atlas	ENSG00000157873 (Hs)
KEGG Gene	hsa:8764 (Hs), mmu:230979 (Mm), rno:366518 (Rn)
OMIM	602746 (Hs)
Pharos	Q92956 (Hs)
UniProtKB	Q92956 (Hs)
Wikipedia	TNFRSF14 (Hs)

Natural/Endogenous Ligands
B and T lymphocyte attenuator {Sp: Human}
LIGHT {Sp: Human}
lymphotoxin-α {Sp: Human}

Adaptor proteins (Human)

TRAF2, TRAF3, TRAF5

Other Binding Ligands
Key to terms and symbols		Click column headers to sort
Ligand Sp. Action Value Parameter Reference B and T lymphocyte attenuator {Sp: Human} Hs - - - ⤷ lymphotoxin-α {Sp: Human} Hs - - - ⤷ LIGHT {Sp: Human} Hs - - - ⤷

Immunopharmacology Comments

HSV viral envelope glycoprotein D (gD) binds to this protein and thereby gains entry to the cell. HVEM binds to several TRAFadaptor proteins to mediate intracellular signalling and activation of the immune response.

Immuno Process Associations

Immuno Process:  Inflammation GO Annotations:  Associated to 2 GO processes GO:2000406 positive regulation of T cell migration IBA click arrow to show/hide IEA associations GO:0045087 innate immune response IEA

Immuno Process:  T cell (activation) GO Annotations:  Associated to 4 GO processes GO:0031295 T cell costimulation IDA GO:0046642 negative regulation of alpha-beta T cell proliferation IBA GO:1905675 negative regulation of adaptive immune memory response IDA click arrow to show/hide IEA associations GO:0002250 adaptive immune response IEA

Immuno Process:  Immune regulation GO Annotations:  Associated to 5 GO processes GO:0002720 positive regulation of cytokine production involved in immune response IBA GO:0031295 T cell costimulation IDA GO:0046642 negative regulation of alpha-beta T cell proliferation IBA GO:1905675 negative regulation of adaptive immune memory response IDA GO:2000406 positive regulation of T cell migration IBA

Immuno Process:  Cytokine production & signalling GO Annotations:  Associated to 2 GO processes GO:0002720 positive regulation of cytokine production involved in immune response IBA GO:0005031 tumor necrosis factor receptor activity TAS

Immuno Process:  Chemotaxis & migration GO Annotations:  Associated to 3 GO processes GO:0031295 T cell costimulation IDA GO:0046642 negative regulation of alpha-beta T cell proliferation IBA GO:2000406 positive regulation of T cell migration IBA

Immuno Process:  B cell (activation) GO Annotations:  Associated to 2 GO processes, IEA only GO:1905675 negative regulation of adaptive immune memory response IDA click arrow to show/hide IEA associations GO:0002250 adaptive immune response IEA

Immuno Process:  Cellular signalling GO Annotations:  Associated to 2 GO processes GO:0031295 T cell costimulation IDA GO:0046642 negative regulation of alpha-beta T cell proliferation IBA

Immuno Process:  Barrier integrity GO Annotations:  Associated to 1 GO processes, IEA only click arrow to show/hide IEA associations GO:0001618 virus receptor activity IEA