Immune checkpoint catalytic receptors

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Catalytic receptors
Immune checkpoint catalytic receptors

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Receptors

CD40 / TNFRSF5 C Show summary »« Hide summary More detailed page go icon to follow link

Target Id

1874

Nomenclature

CD40

Systematic nomenclature

TNFRSF5

Previous and unofficial names

CD40 molecule, TNF receptor superfamily member 5 | TNFRSF5

Genes

CD40 (Hs), Cd40 (Mm), Cd40 (Rn)

Ensembl ID

ENSG00000101017 (Hs), ENSMUSG00000017652 (Mm), ENSRNOG00000018488 (Rn)

UniProtKB AC

P25942 (Hs), P27512 (Mm)

Adaptor proteins

TRAF1, TRAF2, TRAF3, TRAF5, TRAF6

Endogenous ligands

CD40 ligand (CD40LG, P29965)

HVEM (herpes virus entry mediator / TNFRSF14) C Show summary »« Hide summary More detailed page go icon to follow link

Target Id

1887

Nomenclature

herpes virus entry mediator

Systematic nomenclature

TNFRSF14

Common abbreviation

HVEM

Previous and unofficial names

Genes

TNFRSF14 (Hs), Tnfrsf14 (Mm), Tnfrsf14 (Rn)

Ensembl ID

ENSG00000157873 (Hs), ENSMUSG00000042333 (Mm), ENSRNOG00000013820 (Rn)

UniProtKB AC

Q92956 (Hs)

Adaptor proteins

TRAF2, TRAF3, TRAF5

Endogenous ligands

B and T lymphocyte attenuator (BTLA, Q7Z6A9)

lymphotoxin-α (LTA, P01374)

LIGHT (TNFSF14, O43557)

How to cite this family page

Database page citation:

Immune checkpoint catalytic receptors. Accessed on 15/04/2026. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=953.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Peach CJ, Gibb AJ, Kelly E, Mathie AA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Southan C, Davies JA et al. (2025) The Concise Guide to PHARMACOLOGY 2025/26: Catalytic receptors. Br J Pharmacol. 182: S259-S306.