B and T lymphocyte attenuator   Click here for help

GtoPdb Ligand ID: 4891

Abbreviated name: BTLA
Synonyms: B- and T-lymphocyte attenuator  | B- and T-lymphocyte-associated protein | CD272
Immunopharmacology Ligand
Compound class: Endogenous peptide in human, mouse or rat
Comment: BTLA is a negative immunomodulator. Interaction of BTLA with TNFRSF14 (HVEM) constitutes an immune checkpoint which inhibits T cell-mediated immune responses. Dysregulated BTLA expression contributes to immunosuppression and progression of some cancers [3-6] by enabling tumour immune evasion. Immunotherapeutics that block the BTLA-HVEM checkpoint offer potential as anti-tumour agents [7-8]. In the setting of inflammatory diseases anti-BTLA antibodies can induce inhibitory signalling and T cell activation, and reduce cytokine secretion [1].

There is information confirming two anti-BTLA monoclonals that were progressed to clinical development: HFB200603 (HiFiBiO; Phase 1 NCT05789069, solid tumours) [2] and ANB032 (AnaptysBio; Phase 2 NCT05935085, atopic dermatitis; terminated due to insufficient efficacy) [1].
Species: Human
Classification Click here for help
Compound class Endogenous peptide in human, mouse or rat
Ligand families/groups CD molecules (ligands)
Synonyms Click here for help
B- and T-lymphocyte attenuator  | B- and T-lymphocyte-associated protein | CD272
Gene/Precursor Click here for help
Gene symbol Gene name Species Precursor protein name Synonyms
BTLA B and T lymphocyte associated Human prepro-B- and T-lymphocyte attenuator BTLA1, CD272
Database Links Click here for help
CATH/Gene3D 2.60.40.10
Ensembl Gene ENSG00000186265 (Hs)
Entrez Gene 151888 (Hs)
GtoPdb PubChem SID 178101591
Human Protein Atlas ENSG00000186265 (Hs)
UniProtKB Q7Z6A9 (Hs)
Wikipedia BTLA