Quaternary Structure: Complexes

Interleukin-22α1/20β heteromer

Interleukin-22α1/10β heteromer

Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	1	574	1p36.11	IL22RA1	interleukin 22 receptor subunit alpha 1
Mouse	1	581	4 67.99 cM	Il22ra1	interleukin 22 receptor, alpha 1
Rat	-	-		Il22ra1	interleukin 22 receptor subunit alpha 1

Previous and Unofficial Names

CRF2-9 | IL22R | interleukin-22 receptor subunit alpha-1 | interleukin 22 receptor, alpha 1

Database Links
Alphafold	Q8N6P7 (Hs), Q80XZ4 (Mm)
CATH/Gene3D	2.60.40.10
ChEMBL Target	CHEMBL4804251 (Hs)
Ensembl Gene	ENSG00000142677 (Hs), ENSMUSG00000037157 (Mm), ENSRNOG00000066331 (Rn)
Entrez Gene	58985 (Hs), 230828 (Mm), 362629 (Rn)
Human Protein Atlas	ENSG00000142677 (Hs)
KEGG Gene	hsa:58985 (Hs), mmu:230828 (Mm), rno:362629 (Rn)
OMIM	605457 (Hs)
Pharos	Q8N6P7 (Hs)
UniProtKB	Q8N6P7 (Hs), Q80XZ4 (Mm)
Wikipedia	IL22RA1 (Hs)

Immunopharmacology Comments

IL22RA1 is a subunit in the heterodimeric receptors for interleukins 20 and 24 (which bind to the interleukin-22α1/20β heteromer) and IL-22 (which binds to the interleukin-22α1/10β heteromer).

Immuno Process Associations

Immuno Process:  Cytokine production & signalling GO Annotations:  Associated to 4 GO processes GO:0004896 cytokine receptor activity IBA GO:0004904 interferon receptor activity TAS GO:0019221 cytokine-mediated signaling pathway IBA GO:0042018 interleukin-22 receptor activity ISS

Immuno Process:  Immune regulation GO Annotations:  Associated to 1 GO processes GO:0050728 negative regulation of inflammatory response ISS

Immuno Process:  Inflammation GO Annotations:  Associated to 1 GO processes GO:0050728 negative regulation of inflammatory response ISS