Quaternary Structure: Complexes

Thymic stromal lymphopoietin receptor

Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	1	371	Xp22.3 and Yp11.3	CRLF2	cytokine receptor like factor 2
Mouse	1	359	5 F	Crlf2	cytokine receptor-like factor 2
Rat	1	360	14p22	Crlf2	cytokine receptor-like factor 2

Previous and Unofficial Names

thymic stromal lymphopoietin protein receptor | Tpte2 | TSLP receptor | Ly114 | CRL2 | transmembrane phosphoinositide 3-phosphatase and tensin homolog 2

Database Links
Alphafold	Q9HC73 (Hs), Q8CII9 (Mm), Q8R4S8 (Rn)
CATH/Gene3D	2.60.40.10
Ensembl Gene	ENSG00000205755 (Hs), ENSMUSG00000033467 (Mm), ENSRNOG00000049828 (Rn)
Entrez Gene	64109 (Hs), 57914 (Mm), 171499 (Rn)
Human Protein Atlas	ENSG00000205755 (Hs)
KEGG Gene	hsa:64109 (Hs), mmu:57914 (Mm), rno:171499 (Rn)
OMIM	300357 (Hs)
Pharos	Q9HC73 (Hs)
UniProtKB	Q9HC73 (Hs), Q8CII9 (Mm), Q8R4S8 (Rn)
Wikipedia	CRLF2 (Hs)

Immunopharmacology Comments

Cytokine receptor-like factor 2 is the signal transducing subunit of the functional heterodimeric receptor for thymic stromal lymphopoietin (TSLP). Ligand binding is attributed to the interleukin-7 receptor subunit α.

Immuno Process Associations

Immuno Process:  Inflammation

Immuno Process:  Immune regulation

Immuno Process:  Cytokine production & signalling

Immuno Process:  Cellular signalling

Immuno Process:  B cell (activation)

Immuno Process:  T cell (activation)