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serine/threonine kinase 32A

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Target id: 1537

Nomenclature: serine/threonine kinase 32A

Abbreviated Name: YANK1

Family: YANK family

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 396 5q32 STK32A serine/threonine kinase 32A
Mouse - 398 18 B3 Stk32a serine/threonine kinase 32A
Rat - 397 18p11 Stk32a serine/threonine kinase 32A
Database Links Click here for help
Alphafold Q8WU08 (Hs), Q8BGW6 (Mm)
BRENDA 2.7.11.1
ChEMBL Target CHEMBL6150 (Hs)
Ensembl Gene ENSG00000169302 (Hs), ENSMUSG00000039954 (Mm), ENSRNOG00000027066 (Rn)
Entrez Gene 202374 (Hs), 269019 (Mm), 364858 (Rn)
Human Protein Atlas ENSG00000169302 (Hs)
KEGG Enzyme 2.7.11.1
KEGG Gene hsa:202374 (Hs), mmu:269019 (Mm), rno:364858 (Rn)
Pharos Q8WU08 (Hs)
RefSeq Nucleotide NM_001112724 (Hs), NM_178749 (Mm), NM_001191894 (Rn)
RefSeq Protein NP_001106195 (Hs), NP_848864 (Mm), NP_001178823 (Rn)
UniProtKB Q8WU08 (Hs), Q8BGW6 (Mm)
Wikipedia STK32A (Hs)
Selected 3D Structures Click here for help
Image of receptor 3D structure from RCSB PDB
Description:  Crystal structure of human serine/threonine-protein kinase 32A (YANK1).
PDB Id:  4FR4
Resolution:  2.29Å
Species:  Human
References: 
Enzyme Reaction Click here for help
EC Number: 2.7.11.1
DiscoveRx KINOMEscan® screen Click here for help
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform.
http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan
Reference: 1-2
Key to terms and symbols Click column headers to sort
Target used in screen: YANK1
Ligand Sp. Type Action Value Parameter
staurosporine Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 7.9 pKd
NVP-TAE684 Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 7.9 pKd
linifanib Small molecule or natural product Hs Inhibitor Inhibition 6.2 pKd
PP-242 Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 6.2 pKd
SB203580 Small molecule or natural product Immunopharmacology Ligand Hs Inhibitor Inhibition 5.9 pKd
bosutinib Small molecule or natural product Approved drug Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition 5.7 pKd
lestaurtinib Small molecule or natural product Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition 5.7 pKd
tamatinib Small molecule or natural product Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition 5.6 pKd
midostaurin Small molecule or natural product Approved drug Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition 5.6 pKd
PD-173955 Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 5.6 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »

References

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1. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol, 29 (11): 1046-51. [PMID:22037378]

2. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem Biol, 17 (11): 1241-9. [PMID:21095574]

How to cite this page

YANK family: serine/threonine kinase 32A. Last modified on 18/08/2014. Accessed on 15/10/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=1537.